MYF5 (myogenic factor 5)

2008-07-01  

Identity

HGNC
LOCATION
12q21.31
LOCUSID
ALIAS
EORVA,bHLHc2

Other Information

Locus ID:

NCBI: 4617
MIM: 159990
HGNC: 7565
Ensembl: ENSG00000111049

Variants:

dbSNP: 4617
ClinVar: 4617
TCGA: ENSG00000111049
COSMIC: MYF5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111049ENST00000228644P13349

Expression (GTEx)

0
1
2
3

Pathways

PathwaySourceExternal ID
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Developmental BiologyREACTOMER-HSA-1266738
MyogenesisREACTOMER-HSA-525793
CDO in myogenesisREACTOMER-HSA-375170

References

Pubmed IDYearTitleCitations
166143552006Efficacy of 3 days/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs. older adults.129
198297082009DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferation.31
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
122042802002Expression of the myogenic regulatory factor Mrf4 precedes or is contemporaneous with that of Myf5 in the somitic bud.16
280809602017Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma.16
121052042002The myogenic basic helix-loop-helix family of transcription factors shows similar requirements for SWI/SNF chromatin remodeling enzymes during muscle differentiation in culture.13
245950982014Pitx2c is reactivated in the failing myocardium and stimulates myf5 expression in cultured cardiomyocytes.3
298443452018SNAIL is a key regulator of alveolar rhabdomyosarcoma tumor growth and differentiation through repression of MYF5 and MYOD function.3
191920462009Altered binding of MYF-5 to FOXE1 promoter in non-syndromic and CHARGE-associated cleft palate.2
218100802011Efficient in vitro myogenic reprogramming of human primary mesenchymal stem cells and endothelial cells by Myf5.1

Citation

Dessen P

MYF5 (myogenic factor 5)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50169/myf5-(myogenic-factor-5)