Identity
HGNC
LOCATION
19p13.11
LOCUSID
ALIAS
HUPF1,NORF1,RENT1,UTF,pNORF1,smg-2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5976
MIM: 601430
HGNC: 9962
Ensembl: ENSG00000005007
Variants:
dbSNP: 5976
ClinVar: 5976
TCGA: ENSG00000005007
COSMIC: UPF1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000005007 | ENST00000262803 | Q92900 |
| ENSG00000005007 | ENST00000262803 | A0A024R7L5 |
| ENSG00000005007 | ENST00000599848 | Q92900 |
| ENSG00000005007 | ENST00000599848 | A0A024R7L8 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37120495 | 2024 | LncRNA GAS5 regulated by FTO-mediated m6A demethylation promotes autophagic cell death in NSCLC by targeting UPF1/BRD4 axis. | 4 |
| 38013127 | 2024 | LINC02561 promotes metastasis in HCC via HIF1-α/NDRG1/UPF1 axis. | 0 |
| 38167913 | 2024 | Role of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells. | 0 |
| 38244688 | 2024 | Nonsense-mediated mRNA decay affects hyperactive root formation in oculo-facio-cardio-dental syndrome via up-frameshift protein 1. | 0 |
| 38412299 | 2024 | UPF1 ATPase autoinhibition and activation modulate RNA binding kinetics and NMD efficiency. | 0 |
| 38625794 | 2024 | UPF1 regulates mRNA stability by sensing poorly translated coding sequences. | 0 |
| 38709891 | 2024 | UPF1 helicase orchestrates mutually exclusive interactions with the SMG6 endonuclease and UPF2. | 0 |
| 37120495 | 2024 | LncRNA GAS5 regulated by FTO-mediated m6A demethylation promotes autophagic cell death in NSCLC by targeting UPF1/BRD4 axis. | 4 |
| 38013127 | 2024 | LINC02561 promotes metastasis in HCC via HIF1-α/NDRG1/UPF1 axis. | 0 |
| 38167913 | 2024 | Role of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells. | 0 |
| 38244688 | 2024 | Nonsense-mediated mRNA decay affects hyperactive root formation in oculo-facio-cardio-dental syndrome via up-frameshift protein 1. | 0 |
| 38412299 | 2024 | UPF1 ATPase autoinhibition and activation modulate RNA binding kinetics and NMD efficiency. | 0 |
| 38625794 | 2024 | UPF1 regulates mRNA stability by sensing poorly translated coding sequences. | 0 |
| 38709891 | 2024 | UPF1 helicase orchestrates mutually exclusive interactions with the SMG6 endonuclease and UPF2. | 0 |
| 36456182 | 2023 | Modulation of RNA-binding properties of the RNA helicase UPF1 by its activator UPF2. | 6 |
Citation
Dessen P
UPF1 (UPF1 RNA helicase and ATPase)
Atlas Genet Cytogenet Oncol Haematol. 2008-07-01
Online version: http://atlasgeneticsoncology.org/gene/50179/upf1-(upf1-rna-helicase-and-atpase)
