MIR16-1 (microRNA 16-1)

2008-07-01  

Identity

HGNC
MIR16-1
LOCATION
13q14.2
LOCUSID
406950
ALIAS
MIRN16-1,miRNA16-1,mir-16-1

Other Information

Locus ID:

NCBI: 406950
MIM: 609704
HGNC: 31545
Ensembl: ENSG00000208006
miRBase:

Variants:

dbSNP: 406950
ClinVar: 406950
TCGA: ENSG00000208006
COSMIC: MIR16-1

RNA/Proteins

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206

References

Pubmed IDYearTitleCitations
161662622005miR-15 and miR-16 induce apoptosis by targeting BCL2.1144
184498912008miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells.249
218858512011MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1.92
212058912011MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13.78
220491532012The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2.75
214543772011MiR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation by targeting cyclin E.74
208762852010Oncogenic HER2{Delta}16 suppresses miR-15a/16 and deregulates BCL-2 to promote endocrine resistance of breast tumors.71
184833942008Truncation in CCND1 mRNA alters miR-16-1 regulation in mantle cell lymphoma.62
220023112012Myc represses miR-15a/miR-16-1 expression through recruitment of HDAC3 in mantle cell and other non-Hodgkin B-cell lymphomas.60
229228272012miR-15a and miR-16-1 downregulate CCND1 and induce apoptosis and cell cycle arrest in osteosarcoma.47

Citation

Dessen P

MIR16-1 (microRNA 16-1)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50185/mir16-1-(microrna-16-1)