PAG1 (phosphoprotein membrane anchor with glycosphingolipid microdomains 1)

2008-07-01  

Identity

HGNC
LOCATION
8q21.13
LOCUSID
ALIAS
CBP,PAG
FUSION GENES

Other Information

Locus ID:

NCBI: 55824
MIM: 605767
HGNC: 30043
Ensembl: ENSG00000076641

Variants:

dbSNP: 55824
ClinVar: 55824
TCGA: ENSG00000076641
COSMIC: PAG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000076641ENST00000220597Q9NWQ8

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Phosphorylation of CD3 and TCR zeta chainsREACTOMER-HSA-202427
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GAB1 signalosomeREACTOMER-HSA-180292

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
378521062023The role of phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) in regulating the progression of oral squamous cell carcinoma.0
378521062023The role of phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) in regulating the progression of oral squamous cell carcinoma.0
340837542021Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells.9
340837542021Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells.9
327261672020PAG1 directs SRC-family kinase intracellular localization to mediate receptor tyrosine kinase-induced differentiation.5
332154262020PAG1 stimulates proliferation and metastasis of nasopharyngeal carcinoma through downregulating PTEN.5
327261672020PAG1 directs SRC-family kinase intracellular localization to mediate receptor tyrosine kinase-induced differentiation.5
332154262020PAG1 stimulates proliferation and metastasis of nasopharyngeal carcinoma through downregulating PTEN.5
299131532018PAG1 promotes the inherent radioresistance of laryngeal cancer cells via activation of STAT3.7
299131532018PAG1 promotes the inherent radioresistance of laryngeal cancer cells via activation of STAT3.7
290791892017Upregulation of PAG1/Cbp contributes to adipose-derived mesenchymal stem cells promoted tumor progression and chemoresistance in breast cancer.13
290791892017Upregulation of PAG1/Cbp contributes to adipose-derived mesenchymal stem cells promoted tumor progression and chemoresistance in breast cancer.13
269936022016Transmembrane adaptor protein PAG1 is a novel tumor suppressor in neuroblastoma.15
269936022016Transmembrane adaptor protein PAG1 is a novel tumor suppressor in neuroblastoma.15
250055922015Sequencing and expression analyses of the synaptic lipid raft adapter gene PAG1 in schizophrenia.1

Citation

Dessen P

PAG1 (phosphoprotein membrane anchor with glycosphingolipid microdomains 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50191/pag1-(phosphoprotein-membrane-anchor-with-glycosphingolipid-microdomains-1)