TRIM33 (tripartite motif containing 33)

2003-02-01  

Identity

HGNC
TRIM33
LOCATION
1p13.2
LOCUSID
51592
ALIAS
ECTO,PTC7,RFG7,TF1G,TIF1G,TIF1GAMMA,TIFGAMMA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51592
MIM: 605769
HGNC: 16290
Ensembl: ENSG00000197323

Variants:

dbSNP: 51592
ClinVar: 51592
TCGA: ENSG00000197323
COSMIC: TRIM33

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197323ENST00000358465Q9UPN9
ENSG00000197323ENST00000369543Q9UPN9
ENSG00000197323ENST00000448034H0Y612

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerREACTOMER-HSA-2173793
Downregulation of SMAD2/3:SMAD4 transcriptional activityREACTOMER-HSA-2173795
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382701412024TIF1γ and SMAD4 regulation in colorectal cancer: impact on cell proliferation and liver metastasis.0
386274152024TRIM33 loss in multiple myeloma is associated with genomic instability and sensitivity to PARP inhibitors.0
382701412024TIF1γ and SMAD4 regulation in colorectal cancer: impact on cell proliferation and liver metastasis.0
386274152024TRIM33 loss in multiple myeloma is associated with genomic instability and sensitivity to PARP inhibitors.0
374820912023Tubular cell transcriptional intermediary factor 1γ deficiency exacerbates kidney injury-induced tubular cell polyploidy and fibrosis.0
378596252023Tripartite motif containing 33 demonstrated anticancer effect by degrading c‑Myc: Limitation of glutamine metabolism and proliferation in endometrial carcinoma cells.0
374820912023Tubular cell transcriptional intermediary factor 1γ deficiency exacerbates kidney injury-induced tubular cell polyploidy and fibrosis.0
378596252023Tripartite motif containing 33 demonstrated anticancer effect by degrading c‑Myc: Limitation of glutamine metabolism and proliferation in endometrial carcinoma cells.0
357854142022TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.7
359291412022Downregulation of TRIM33 Promotes Survival and Epithelial-Mesenchymal Transition in Gastric Cancer.0
360968612022E3 ubiquitin ligase Trim33 ubiquitylates Annexin A2 to promote NF-κB induced skin inflammation in psoriasis.0
357854142022TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.7
359291412022Downregulation of TRIM33 Promotes Survival and Epithelial-Mesenchymal Transition in Gastric Cancer.0
360968612022E3 ubiquitin ligase Trim33 ubiquitylates Annexin A2 to promote NF-κB induced skin inflammation in psoriasis.0
327701072021PIAS1 and TIF1γ collaborate to promote SnoN SUMOylation and suppression of epithelial-mesenchymal transition.9

Citation

Dessen P

TRIM33 (tripartite motif containing 33)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/502/trim33-(tripartite-motif-containing-33)