Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51141
MIM: 608660
HGNC: 20452
Ensembl: ENSG00000125629
Variants:
dbSNP: 51141
ClinVar: 51141
TCGA: ENSG00000125629
COSMIC: INSIG2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000125629 | ENST00000245787 | Q9Y5U4 |
| ENSG00000125629 | ENST00000245787 | A0A024RAI2 |
| ENSG00000125629 | ENST00000411929 | F8WCG8 |
| ENSG00000125629 | ENST00000614681 | A0A0C4DGZ4 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism | REACTOME | R-HSA-1430728 |
| Metabolism of lipids and lipoproteins | REACTOME | R-HSA-556833 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | REACTOME | R-HSA-1655829 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA162370415 | Metabolic Syndrome | Disease | VariantAnnotation | associated | PD | 20877301 | |
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 18195716, 20373477, 20877301 | |
| PA452233 | antipsychotics | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 18195716, 20373477, 20877301 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38287498 | 2024 | Genome-wide loss-of-function genetic screen identifies INSIG2 as the vulnerability of hepatitis B virus-integrated hepatoma cells. | 1 |
| 38287498 | 2024 | Genome-wide loss-of-function genetic screen identifies INSIG2 as the vulnerability of hepatitis B virus-integrated hepatoma cells. | 1 |
| 36515824 | 2023 | Insulin-induced gene 2 expression is associated with cervical adenocarcinoma malignant behavior. | 1 |
| 36515824 | 2023 | Insulin-induced gene 2 expression is associated with cervical adenocarcinoma malignant behavior. | 1 |
| 33321090 | 2021 | Insulin-Induced Gene 2 Expression Is Associated with Breast Cancer Metastasis. | 0 |
| 33446483 | 2021 | A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. | 30 |
| 33586351 | 2021 | Polymorphic variants INSIG2 rs6726538, HLA-DRB1 rs9272143, and GCNT1P5 rs7780883 contribute to the susceptibility of cervical cancer in the Bangladeshi women. | 2 |
| 34192549 | 2021 | Structural basis for sterol sensing by Scap and Insig. | 11 |
| 34298014 | 2021 | Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK-eIF2α-ATF4 axis. | 2 |
| 34315947 | 2021 | Association of CNR1 and INSIG2 polymorphisms with antipsychotics-induced weight gain: a prospective nested case-control study. | 0 |
| 33321090 | 2021 | Insulin-Induced Gene 2 Expression Is Associated with Breast Cancer Metastasis. | 0 |
| 33446483 | 2021 | A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. | 30 |
| 33586351 | 2021 | Polymorphic variants INSIG2 rs6726538, HLA-DRB1 rs9272143, and GCNT1P5 rs7780883 contribute to the susceptibility of cervical cancer in the Bangladeshi women. | 2 |
| 34192549 | 2021 | Structural basis for sterol sensing by Scap and Insig. | 11 |
| 34298014 | 2021 | Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK-eIF2α-ATF4 axis. | 2 |
Citation
Dessen P
INSIG2 (insulin induced gene 2)
Atlas Genet Cytogenet Oncol Haematol. 2008-07-01
Online version: http://atlasgeneticsoncology.org/gene/50205/insig2-(insulin-induced-gene-2)
