Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 79890
MIM: 610223
HGNC: 18751
Ensembl: ENSG00000100599
Variants:
dbSNP: 79890
ClinVar: 79890
TCGA: ENSG00000100599
COSMIC: RIN3
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Vesicle-mediated transport | REACTOME | R-HSA-5653656 |
| Membrane Trafficking | REACTOME | R-HSA-199991 |
| RAB GEFs exchange GTP for GDP on RABs | REACTOME | R-HSA-8876198 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35241726 | 2022 | The neuronal-specific isoform of BIN1 regulates β-secretase cleavage of APP and Aβ generation in a RIN3-dependent manner. | 11 |
| 35241726 | 2022 | The neuronal-specific isoform of BIN1 regulates β-secretase cleavage of APP and Aβ generation in a RIN3-dependent manner. | 11 |
| 30726512 | 2019 | Genetic Variation in RIN3 in the Belgian Population Supports Its Involvement in the Pathogenesis of Paget's Disease of Bone and Modifies the Age of Onset. | 4 |
| 30726512 | 2019 | Genetic Variation in RIN3 in the Belgian Population Supports Its Involvement in the Pathogenesis of Paget's Disease of Bone and Modifies the Age of Onset. | 4 |
| 28738127 | 2017 | Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport. | 21 |
| 28738127 | 2017 | Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport. | 21 |
| 25701875 | 2015 | Targeted sequencing of the Paget's disease associated 14q32 locus identifies several missense coding variants in RIN3 that predispose to Paget's disease of bone. | 16 |
| 26296892 | 2015 | Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3). | 21 |
| 25701875 | 2015 | Targeted sequencing of the Paget's disease associated 14q32 locus identifies several missense coding variants in RIN3 that predispose to Paget's disease of bone. | 16 |
| 26296892 | 2015 | Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3). | 21 |
| 24945404 | 2014 | Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment. | 84 |
| 24945404 | 2014 | Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment. | 84 |
| 23185384 | 2012 | RIN3 is a negative regulator of mast cell responses to SCF. | 9 |
| 23185384 | 2012 | RIN3 is a negative regulator of mast cell responses to SCF. | 9 |
| 21586568 | 2011 | Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31. | 33 |
Citation
Dessen P
RIN3 (Ras and Rab interactor 3)
Atlas Genet Cytogenet Oncol Haematol. 2008-07-01
Online version: http://atlasgeneticsoncology.org/gene/50206/rin3-(ras-and-rab-interactor-3)
