EME2 (essential meiotic structure-specific endonuclease subunit 2)

2008-07-01  

Identity

HGNC
EME2
LOCATION
16p13.3
LOCUSID
197342
ALIAS
SLX2B,gs125
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 197342
MIM: 610886
HGNC: 27289
Ensembl: ENSG00000197774

Variants:

dbSNP: 197342
ClinVar: 197342
TCGA: ENSG00000197774
COSMIC: EME2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197774ENST00000561903H3BV62
ENSG00000197774ENST00000564182H3BSZ6
ENSG00000197774ENST00000568449A4GXA9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Resolution of D-Loop StructuresREACTOMER-HSA-5693537
Resolution of D-loop Structures through Holliday Junction IntermediatesREACTOMER-HSA-5693568
Fanconi Anemia PathwayREACTOMER-HSA-6783310

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
352907972022Crystal structure of the human MUS81-EME2 complex.3
352907972022Crystal structure of the human MUS81-EME2 complex.3
268049042016Signaling from Mus81-Eme2-Dependent DNA Damage Elicited by Chk1 Deficiency Modulates Replication Fork Speed and Origin Usage.41
268049042016Signaling from Mus81-Eme2-Dependent DNA Damage Elicited by Chk1 Deficiency Modulates Replication Fork Speed and Origin Usage.41
243712682014Substrate specificity of the MUS81-EME2 structure selective endonuclease.35
246926622014Human MUS81-EME2 can cleave a variety of DNA structures including intact Holliday junction and nicked duplex.22
248138862014MUS81-EME2 promotes replication fork restart.68
243712682014Substrate specificity of the MUS81-EME2 structure selective endonuclease.35
246926622014Human MUS81-EME2 can cleave a variety of DNA structures including intact Holliday junction and nicked duplex.22
248138862014MUS81-EME2 promotes replication fork restart.68

Citation

Dessen P

EME2 (essential meiotic structure-specific endonuclease subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50227/eme2-(essential-meiotic-structure-specific-endonuclease-subunit-2)