Identity
HGNC
LOCATION
15q25.1
LOCUSID
ALIAS
Eaf3,FWP006,HsT17725,MEAF3,MORFRG15,MRG15,S863-6
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10933
MIM: 607303
HGNC: 16989
Ensembl: ENSG00000185787
Variants:
dbSNP: 10933
ClinVar: 10933
TCGA: ENSG00000185787
COSMIC: MORF4L1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Chromatin organization | REACTOME | R-HSA-4839726 |
| Chromatin modifying enzymes | REACTOME | R-HSA-3247509 |
| HATs acetylate histones | REACTOME | R-HSA-3214847 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37527654 | 2023 | MRG15 activates histone methyltransferase activity of ASH1L by recruiting it to the nucleosomes. | 1 |
| 37527654 | 2023 | MRG15 activates histone methyltransferase activity of ASH1L by recruiting it to the nucleosomes. | 1 |
| 35985547 | 2022 | MRG15 aggravates non-alcoholic steatohepatitis progression by regulating the mitochondrial proteolytic degradation of TUFM. | 8 |
| 35985547 | 2022 | MRG15 aggravates non-alcoholic steatohepatitis progression by regulating the mitochondrial proteolytic degradation of TUFM. | 8 |
| 34946951 | 2021 | Structural Insight into the Mechanism of PALB2 Interaction with MRG15. | 2 |
| 34946951 | 2021 | Structural Insight into the Mechanism of PALB2 Interaction with MRG15. | 2 |
| 30827841 | 2019 | Structural Basis of MRG15-Mediated Activation of the ASH1L Histone Methyltransferase by Releasing an Autoinhibitory Loop. | 13 |
| 30827843 | 2019 | Structural Insights into Stimulation of Ash1L's H3K36 Methyltransferase Activity through Mrg15 Binding. | 14 |
| 30827841 | 2019 | Structural Basis of MRG15-Mediated Activation of the ASH1L Histone Methyltransferase by Releasing an Autoinhibitory Loop. | 13 |
| 30827843 | 2019 | Structural Insights into Stimulation of Ash1L's H3K36 Methyltransferase Activity through Mrg15 Binding. | 14 |
| 28673974 | 2017 | MRG15-mediated tethering of PALB2 to unperturbed chromatin protects active genes from genotoxic stress. | 27 |
| 28673974 | 2017 | MRG15-mediated tethering of PALB2 to unperturbed chromatin protects active genes from genotoxic stress. | 27 |
| 22728643 | 2012 | Sequence requirements for combinatorial recognition of histone H3 by the MRG15 and Pf1 subunits of the Rpd3S/Sin3S corepressor complex. | 17 |
| 22728643 | 2012 | Sequence requirements for combinatorial recognition of histone H3 by the MRG15 and Pf1 subunits of the Rpd3S/Sin3S corepressor complex. | 17 |
| 21466675 | 2011 | Exploring the link between MORF4L1 and risk of breast cancer. | 13 |
Citation
Dessen P
MORF4L1 (mortality factor 4 like 1)
Atlas Genet Cytogenet Oncol Haematol. 2008-07-01
Online version: http://atlasgeneticsoncology.org/gene/50247/morf4l1-(mortality-factor-4-like-1)
