MORF4L1 (mortality factor 4 like 1)

2008-07-01  

Identity

HGNC
LOCATION
15q25.1
LOCUSID
ALIAS
Eaf3,FWP006,HsT17725,MEAF3,MORFRG15,MRG15,S863-6
FUSION GENES

Other Information

Locus ID:

NCBI: 10933
MIM: 607303
HGNC: 16989
Ensembl: ENSG00000185787

Variants:

dbSNP: 10933
ClinVar: 10933
TCGA: ENSG00000185787
COSMIC: MORF4L1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185787ENST00000331268Q9UBU8
ENSG00000185787ENST00000379535B3KTM8
ENSG00000185787ENST00000426013Q9UBU8
ENSG00000185787ENST00000558502Q9UBU8
ENSG00000185787ENST00000558746H0YLJ3
ENSG00000185787ENST00000558830H0YMT8
ENSG00000185787ENST00000559158H0YM21
ENSG00000185787ENST00000559244H0YNI8
ENSG00000185787ENST00000559345Q9UBU8
ENSG00000185787ENST00000559690H0YLV1
ENSG00000185787ENST00000559751H0YNE0
ENSG00000185787ENST00000559930H0YNX3
ENSG00000185787ENST00000560422H0YMJ0

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
171352092006Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3.71
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
175737802007RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation.50
123970792002MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation.44
195536772009MRG15 is a novel PALB2-interacting factor involved in homologous recombination.41
203321212010MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks.38
170087232006The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14.13
174601912007The role of the MORF/MRG family of genes in cell growth, differentiation, DNA repair, and thereby aging.12
286739742017MRG15-mediated tethering of PALB2 to unperturbed chromatin protects active genes from genotoxic stress.12
164070742006Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain.11

Citation

Dessen P

MORF4L1 (mortality factor 4 like 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50247/morf4l1-(mortality-factor-4-like-1)