Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 147111
MIM: 609847
HGNC: 27106
Ensembl: ENSG00000185269
Variants:
dbSNP: 147111
ClinVar: 147111
TCGA: ENSG00000185269
COSMIC: NOTUM
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000185269 | ENST00000409678 | Q6P988 |
| ENSG00000185269 | ENST00000425009 | C9JYG8 |
| ENSG00000185269 | ENST00000477214 | K7EIG3 |
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37749430 | 2024 | Notum enhances gastric cancer stem-like cell properties through upregulation of Sox2 by PI3K/AKT signaling pathway. | 1 |
| 38278124 | 2024 | NOTUM plays a bidirectionally modulatory role in the odontoblastic differentiation of human stem cells from the apical papilla through the WNT/β-catenin signaling pathway. | 0 |
| 37749430 | 2024 | Notum enhances gastric cancer stem-like cell properties through upregulation of Sox2 by PI3K/AKT signaling pathway. | 1 |
| 38278124 | 2024 | NOTUM plays a bidirectionally modulatory role in the odontoblastic differentiation of human stem cells from the apical papilla through the WNT/β-catenin signaling pathway. | 0 |
| 36280040 | 2022 | Notum leads to potential pro-survival of OSCC through crosstalk between Shh and Wnt/β-catenin signaling via p-GSK3β. | 4 |
| 36280040 | 2022 | Notum leads to potential pro-survival of OSCC through crosstalk between Shh and Wnt/β-catenin signaling via p-GSK3β. | 4 |
| 33647468 | 2021 | Notum deacylates octanoylated ghrelin. | 9 |
| 34079124 | 2021 | NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. | 83 |
| 34402722 | 2021 | Notum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma. | 3 |
| 33647468 | 2021 | Notum deacylates octanoylated ghrelin. | 9 |
| 34079124 | 2021 | NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. | 83 |
| 34402722 | 2021 | Notum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma. | 3 |
| 31876313 | 2020 | Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum. | 14 |
| 31876313 | 2020 | Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum. | 14 |
| 31292548 | 2019 | Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium. | 92 |
Citation
Dessen P
NOTUM (notum, palmitoleoyl-protein carboxylesterase)
Atlas Genet Cytogenet Oncol Haematol. 2008-07-01
Online version: http://atlasgeneticsoncology.org/gene/50255/notum-(notum-palmitoleoyl-protein-carboxylesterase)
