CXCL11 (C-X-C motif chemokine ligand 11)

2008-07-01  

Identity

HGNC
LOCATION
4q21.1
LOCUSID
ALIAS
H174,I-TAC,IP-9,IP9,SCYB11,SCYB9B,b-R1
FUSION GENES

Other Information

Locus ID:

NCBI: 6373
MIM: 604852
HGNC: 10638
Ensembl: ENSG00000169248

Variants:

dbSNP: 6373
ClinVar: 6373
TCGA: ENSG00000169248
COSMIC: CXCL11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169248ENST00000306621O14625
ENSG00000169248ENST00000503860O14625

Expression (GTEx)

0
1
2
3

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Toll-like receptor signaling pathwayKEGGko04620
Cytokine-cytokine receptor interactionKEGGhsa04060
Toll-like receptor signaling pathwayKEGGhsa04620
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
129492492003Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.154
183166072008EBV microRNAs in primary lymphomas and targeting of CXCL-11 by ebv-mir-BHRF1-3.141
151502612004Intracellular domains of CXCR3 that mediate CXCL9, CXCL10, and CXCL11 function.85
151227502004Expression of the CXCR3 ligand I-TAC by hepatocytes in chronic hepatitis C and its correlation with hepatic inflammation.43
186450412008Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation.42
173637342007Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration.41
158147162005Roles for CXC chemokine ligands 10 and 11 in recruiting CD4+ T cells to HIV-1-infected monocyte-derived macrophages, dendritic cells, and lymph nodes.38
184112832008Matrix metalloproteinase processing of CXCL11/I-TAC results in loss of chemoattractant activity and altered glycosaminoglycan binding.38
160815392005Interferon-alpha and -beta differentially regulate osteoclastogenesis: role of differential induction of chemokine CXCL11 expression.36
128842992003CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11.33

Citation

Dessen P

CXCL11 (C-X-C motif chemokine ligand 11)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50256/cxcl11-(c-x-c-motif-chemokine-ligand-11)