Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55512
MIM: 605777
HGNC: 14240
Ensembl: ENSG00000103056
Variants:
dbSNP: 55512
ClinVar: 55512
TCGA: ENSG00000103056
COSMIC: SMPD3
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38542220 | 2024 | The Role of Neutral Sphingomyelinase-2 (NSM2) in the Control of Neutral Lipid Storage in T Cells. | 1 |
| 38542220 | 2024 | The Role of Neutral Sphingomyelinase-2 (NSM2) in the Control of Neutral Lipid Storage in T Cells. | 1 |
| 36768348 | 2023 | Inhibition of Neutral Sphingomyelinase 2 by Novel Small Molecule Inhibitors Results in Decreased Release of Extracellular Vesicles by Vascular Smooth Muscle Cells and Attenuated Calcification. | 2 |
| 37640282 | 2023 | Regulated translocation of neutral sphingomyelinase-2 to the plasma membrane drives insulin resistance in steatotic hepatocytes. | 2 |
| 36768348 | 2023 | Inhibition of Neutral Sphingomyelinase 2 by Novel Small Molecule Inhibitors Results in Decreased Release of Extracellular Vesicles by Vascular Smooth Muscle Cells and Attenuated Calcification. | 2 |
| 37640282 | 2023 | Regulated translocation of neutral sphingomyelinase-2 to the plasma membrane drives insulin resistance in steatotic hepatocytes. | 2 |
| 33727246 | 2021 | Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti-PD-1 Therapy Efficacy. | 23 |
| 33938457 | 2021 | Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis. | 39 |
| 34584229 | 2021 | Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects. | 14 |
| 34951654 | 2021 | Activation of neutral sphingomyelinase 2 through hyperglycemia contributes to endothelial apoptosis via vesicle-bound intercellular transfer of ceramides. | 6 |
| 33727246 | 2021 | Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti-PD-1 Therapy Efficacy. | 23 |
| 33938457 | 2021 | Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis. | 39 |
| 34584229 | 2021 | Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects. | 14 |
| 34951654 | 2021 | Activation of neutral sphingomyelinase 2 through hyperglycemia contributes to endothelial apoptosis via vesicle-bound intercellular transfer of ceramides. | 6 |
| 30890560 | 2019 | The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme. | 8 |
Citation
Dessen P
SMPD3 (sphingomyelin phosphodiesterase 3)
Atlas Genet Cytogenet Oncol Haematol. 2008-08-01
Online version: http://atlasgeneticsoncology.org/gene/50291/smpd3-(sphingomyelin-phosphodiesterase-3)
