CXCL16 (C-X-C motif chemokine ligand 16)

2008-08-01  

Identity

HGNC
LOCATION
17p13.2
LOCUSID
ALIAS
CXCLG16,SR-PSOX,SRPSOX
FUSION GENES

Other Information

Locus ID:

NCBI: 58191
MIM: 605398
HGNC: 16642
Ensembl: ENSG00000161921

Variants:

dbSNP: 58191
ClinVar: 58191
TCGA: ENSG00000161921
COSMIC: CXCL16

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161921ENST00000293778Q9H2A7
ENSG00000161921ENST00000573123I3L333
ENSG00000161921ENST00000574412Q9H2A7

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381461252024Serum CXCL16: A new predictor of liver inflammation in patients with chronic hepatitis B.0
381461252024Serum CXCL16: A new predictor of liver inflammation in patients with chronic hepatitis B.0
363738772023CXCL16 inhibits epithelial regeneration and promotes fibrosis during the progression of radiation enteritis.2
366704242023Convergent transcriptomic and genomic evidence supporting a dysregulation of CXCL16 and CCL5 in Alzheimer's disease.4
369502182023ELK3-CXCL16 axis determines natural killer cell cytotoxicity via the chemotactic activity of CXCL16 in triple negative breast cancer.1
370869372023Upregulation of IL-33, CCL2, and CXCL16 levels in Brazilian pregnant women infected by Toxoplasma gondii.2
378487262023CXCL5 and CXCL14, but not CXCL16 as potential biomarkers of colorectal cancer.0
380443632023Identification of CXCL16 as a diagnostic biomarker for obesity and intervertebral disc degeneration based on machine learning.1
363738772023CXCL16 inhibits epithelial regeneration and promotes fibrosis during the progression of radiation enteritis.2
366704242023Convergent transcriptomic and genomic evidence supporting a dysregulation of CXCL16 and CCL5 in Alzheimer's disease.4
369502182023ELK3-CXCL16 axis determines natural killer cell cytotoxicity via the chemotactic activity of CXCL16 in triple negative breast cancer.1
370869372023Upregulation of IL-33, CCL2, and CXCL16 levels in Brazilian pregnant women infected by Toxoplasma gondii.2
378487262023CXCL5 and CXCL14, but not CXCL16 as potential biomarkers of colorectal cancer.0
380443632023Identification of CXCL16 as a diagnostic biomarker for obesity and intervertebral disc degeneration based on machine learning.1
348828922022P2X7 receptor inhibition attenuates podocyte injury by oxLDL through deregulating CXCL16.2

Citation

Dessen P

CXCL16 (C-X-C motif chemokine ligand 16)

Atlas Genet Cytogenet Oncol Haematol. 2008-08-01

Online version: http://atlasgeneticsoncology.org/gene/50303/cxcl16-(c-x-c-motif-chemokine-ligand-16)