HRH3 (histamine receptor H3)

2008-08-01  

Identity

HGNC
HRH3
LOCATION
20q13.33
LOCUSID
11255
ALIAS
GPCR97,HH3R
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11255
MIM: 604525
HGNC: 5184
Ensembl: ENSG00000101180

Variants:

dbSNP: 11255
ClinVar: 11255
TCGA: ENSG00000101180
COSMIC: HRH3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101180ENST00000317393A0A0A0MR48
ENSG00000101180ENST00000340177Q9Y5N1
ENSG00000101180ENST00000611492A0A087WZD3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Histamine receptorsREACTOMER-HSA-390650
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD21652606
PA451257risperidoneChemicalClinicalAnnotationassociatedPD21652606

References

Pubmed IDYearTitleCitations
377522202023Recovery of the histamine H(3) receptor activity lost in yeast cells through error-prone PCR and in vivo selection.0
377522202023Recovery of the histamine H(3) receptor activity lost in yeast cells through error-prone PCR and in vivo selection.0
360910662022Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar Automeris zaruma.4
360910662022Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar Automeris zaruma.4
308016952020Histamine, histamine H(3) receptor, and alcohol use disorder.5
330636102020Histamine H(3) receptor gene variants associated with drug abuse in patients with cocaine use disorder.0
308016952020Histamine, histamine H(3) receptor, and alcohol use disorder.5
330636102020Histamine H(3) receptor gene variants associated with drug abuse in patients with cocaine use disorder.0
310023502019Upregulated histamine receptor H3 promotes tumor growth and metastasis in hepatocellular carcinoma.10
310023502019Upregulated histamine receptor H3 promotes tumor growth and metastasis in hepatocellular carcinoma.10
295577082018Differential expression and signaling of the human histamine H(3) receptor isoforms of 445 and 365 amino acids expressed in human neuroblastoma SH-SY5Y cells.0
295577082018Differential expression and signaling of the human histamine H(3) receptor isoforms of 445 and 365 amino acids expressed in human neuroblastoma SH-SY5Y cells.0
281265882017The naturally occurring mutation Y197C does not affect the expression or signaling of the human histamine H(3) receptor.0
292538932017Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination.23
281265882017The naturally occurring mutation Y197C does not affect the expression or signaling of the human histamine H(3) receptor.0

Citation

Dessen P

HRH3 (histamine receptor H3)

Atlas Genet Cytogenet Oncol Haematol. 2008-08-01

Online version: http://atlasgeneticsoncology.org/gene/50307/hrh3-(histamine-receptor-h3)