GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1)

2008-08-01  

Identity

HGNC
GRINA
LOCATION
8q24.3
LOCUSID
2907
ALIAS
HNRGW,LFG1,NMDARA1,TMBIM3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2907
MIM: 138251
HGNC: 4589
Ensembl: ENSG00000178719

Variants:

dbSNP: 2907
ClinVar: 2907
TCGA: ENSG00000178719
COSMIC: GRINA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178719ENST00000313269Q7Z429
ENSG00000178719ENST00000395068Q7Z429
ENSG00000178719ENST00000527194H0YC98
ENSG00000178719ENST00000529301E9PPG3
ENSG00000178719ENST00000530898E9PQF8
ENSG00000178719ENST00000533044H0YCP9
ENSG00000178719ENST00000534791H0YEI4

Expression (GTEx)

0
100
200
300
400
500
600
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
343688712021Glutamate receptor, ionotropic, N‑methyl D‑aspartate‑associated protein 1 promotes colorectal cancer cell proliferation and metastasis, and is negatively regulated by miR‑296‑3p.6
343688712021Glutamate receptor, ionotropic, N‑methyl D‑aspartate‑associated protein 1 promotes colorectal cancer cell proliferation and metastasis, and is negatively regulated by miR‑296‑3p.6
326572162020Glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1, a potential target of miR-296, facilitates proliferation and migration of rectal cancer cells.2
326572162020Glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1, a potential target of miR-296, facilitates proliferation and migration of rectal cancer cells.2
307306092019Prioritization of PLEC and GRINA as Osteoarthritis Risk Genes Through the Identification and Characterization of Novel Methylation Quantitative Trait Loci.20
314264462019Deciphering GRINA/Lifeguard1: Nuclear Location, Ca(2+) Homeostasis and Vesicle Transport.9
307306092019Prioritization of PLEC and GRINA as Osteoarthritis Risk Genes Through the Identification and Characterization of Novel Methylation Quantitative Trait Loci.20
314264462019Deciphering GRINA/Lifeguard1: Nuclear Location, Ca(2+) Homeostasis and Vesicle Transport.9
305415912018Transmembrane protein GRINA modulates aerobic glycolysis and promotes tumor progression in gastric cancer.18
305415912018Transmembrane protein GRINA modulates aerobic glycolysis and promotes tumor progression in gastric cancer.18
269902862016Extraintestinal manifestations of celiac disease: 33-mer gliadin binding to glutamate receptor GRINA as a new explanation.7
269902862016Extraintestinal manifestations of celiac disease: 33-mer gliadin binding to glutamate receptor GRINA as a new explanation.7
257649782015The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA²⁺-filling state.40
257649782015The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA²⁺-filling state.40
222409012012TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis.38

Citation

Dessen P

GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-08-01

Online version: http://atlasgeneticsoncology.org/gene/50312/grina-(glutamate-ionotropic-receptor-nmda-type-subunit-associated-protein-1)