PRKCB (protein kinase C beta)

2008-09-01 Affiliation

Identity

HGNC

PRKCB

LOCATION

16p12.2

LOCUSID

5579

ALIAS

PKC-beta,PKCB,PKCI(2),PKCbeta,PRKCB1,PRKCB2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5579
MIM: 176970
HGNC: 9395
Ensembl: ENSG00000166501

Variants:

dbSNP: 5579
ClinVar: 5579
TCGA: ENSG00000166501
COSMIC: PRKCB

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000166501	ENST00000321728	P05771
ENSG00000166501	ENST00000466124	I3L148
ENSG00000166501	ENST00000472066	H3BV73
ENSG00000166501	ENST00000498739	I3L1Z0
ENSG00000166501	ENST00000643927	P05771

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
ErbB signaling pathway	KEGG	ko04012
Calcium signaling pathway	KEGG	ko04020
Phosphatidylinositol signaling system	KEGG	ko04070
mTOR signaling pathway	KEGG	ko04150
Wnt signaling pathway	KEGG	ko04310
VEGF signaling pathway	KEGG	ko04370
Focal adhesion	KEGG	ko04510
Gap junction	KEGG	ko04540
Natural killer cell mediated cytotoxicity	KEGG	ko04650
B cell receptor signaling pathway	KEGG	ko04662
Leukocyte transendothelial migration	KEGG	ko04670
Long-term potentiation	KEGG	ko04720
Long-term depression	KEGG	ko04730
GnRH signaling pathway	KEGG	ko04912
Melanogenesis	KEGG	ko04916
Glioma	KEGG	ko05214
Non-small cell lung cancer	KEGG	ko05223
MAPK signaling pathway	KEGG	hsa04010
ErbB signaling pathway	KEGG	hsa04012
Calcium signaling pathway	KEGG	hsa04020
Phosphatidylinositol signaling system	KEGG	hsa04070
mTOR signaling pathway	KEGG	hsa04150
Wnt signaling pathway	KEGG	hsa04310
VEGF signaling pathway	KEGG	hsa04370
Focal adhesion	KEGG	hsa04510
Gap junction	KEGG	hsa04540
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
B cell receptor signaling pathway	KEGG	hsa04662
Leukocyte transendothelial migration	KEGG	hsa04670
Long-term potentiation	KEGG	hsa04720
Long-term depression	KEGG	hsa04730
GnRH signaling pathway	KEGG	hsa04912
Melanogenesis	KEGG	hsa04916
Pathways in cancer	KEGG	hsa05200
Glioma	KEGG	hsa05214
Non-small cell lung cancer	KEGG	hsa05223
Vascular smooth muscle contraction	KEGG	hsa04270
Chemokine signaling pathway	KEGG	ko04062
Vascular smooth muscle contraction	KEGG	ko04270
Chemokine signaling pathway	KEGG	hsa04062
Fc gamma R-mediated phagocytosis	KEGG	ko04666
Fc gamma R-mediated phagocytosis	KEGG	hsa04666
Aldosterone-regulated sodium reabsorption	KEGG	ko04960
Aldosterone-regulated sodium reabsorption	KEGG	hsa04960
Leishmaniasis	KEGG	ko05140
Leishmaniasis	KEGG	hsa05140
Salivary secretion	KEGG	ko04970
Salivary secretion	KEGG	hsa04970
Gastric acid secretion	KEGG	ko04971
Gastric acid secretion	KEGG	hsa04971
Amoebiasis	KEGG	ko05146
Amoebiasis	KEGG	hsa05146
Pancreatic secretion	KEGG	ko04972
Pancreatic secretion	KEGG	hsa04972
Carbohydrate digestion and absorption	KEGG	ko04973
Carbohydrate digestion and absorption	KEGG	hsa04973
African trypanosomiasis	KEGG	ko05143
African trypanosomiasis	KEGG	hsa05143
Endocrine and other factor-regulated calcium reabsorption	KEGG	ko04961
Endocrine and other factor-regulated calcium reabsorption	KEGG	hsa04961
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Cholinergic synapse	KEGG	hsa04725
GABAergic synapse	KEGG	ko04727
GABAergic synapse	KEGG	hsa04727
Dopaminergic synapse	KEGG	ko04728
Dopaminergic synapse	KEGG	hsa04728
Serotonergic synapse	KEGG	hsa04726
Retrograde endocannabinoid signaling	KEGG	hsa04723
Retrograde endocannabinoid signaling	KEGG	ko04723
Amphetamine addiction	KEGG	hsa05031
Amphetamine addiction	KEGG	ko05031
Morphine addiction	KEGG	hsa05032
Morphine addiction	KEGG	ko05032
NF-kappa B signaling pathway	KEGG	hsa04064
NF-kappa B signaling pathway	KEGG	ko04064
Hepatitis B	KEGG	hsa05161
HIF-1 signaling pathway	KEGG	hsa04066
Circadian entrainment	KEGG	hsa04713
Circadian entrainment	KEGG	ko04713
Insulin secretion	KEGG	hsa04911
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Thyroid hormone synthesis	KEGG	hsa04918
Thyroid hormone synthesis	KEGG	ko04918
MicroRNAs in cancer	KEGG	hsa05206
MicroRNAs in cancer	KEGG	ko05206
Ras signaling pathway	KEGG	hsa04014
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
Thyroid hormone signaling pathway	KEGG	hsa04919
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
Choline metabolism in cancer	KEGG	hsa05231
Choline metabolism in cancer	KEGG	ko05231
Sphingolipid signaling pathway	KEGG	hsa04071
Sphingolipid signaling pathway	KEGG	ko04071
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME	R-HSA-112314
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity	REACTOME	R-HSA-399721
Trafficking of AMPA receptors	REACTOME	R-HSA-399719
Trafficking of GluR2-containing AMPA receptors	REACTOME	R-HSA-416993
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)	REACTOME	R-HSA-1168372
Activation of NF-kappaB in B cells	REACTOME	R-HSA-1169091
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Response to elevated platelet cytosolic Ca2+	REACTOME	R-HSA-76005
Disinhibition of SNARE formation	REACTOME	R-HSA-114516
Signal Transduction	REACTOME	R-HSA-162582
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (z) signalling events	REACTOME	R-HSA-418597
Signaling by Wnt	REACTOME	R-HSA-195721
Beta-catenin independent WNT signaling	REACTOME	R-HSA-3858494
PCP/CE pathway	REACTOME	R-HSA-4086400
WNT5A-dependent internalization of FZD4	REACTOME	R-HSA-5099900
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Prophase	REACTOME	R-HSA-68875
Nuclear Envelope Breakdown	REACTOME	R-HSA-2980766
Depolymerisation of the Nuclear Lamina	REACTOME	R-HSA-4419969
Aldosterone synthesis and secretion	KEGG	hsa04925
Insulin resistance	KEGG	hsa04931
Aldosterone synthesis and secretion	KEGG	ko04925
AGE-RAGE signaling pathway in diabetic complications	KEGG	ko04933
AGE-RAGE signaling pathway in diabetic complications	KEGG	hsa04933
EGFR tyrosine kinase inhibitor resistance	KEGG	ko01521
EGFR tyrosine kinase inhibitor resistance	KEGG	hsa01521

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA128394595	PLCH1	Gene	Pathway	associated
PA134875646	PLCZ1	Gene	Pathway	associated
PA134914471	PLCH2	Gene	Pathway	associated
PA248	NFKB1	Gene	Pathway	associated
PA27749	ELK1	Gene	Pathway	associated
PA28212	FOS	Gene	Pathway	associated
PA296	RELA	Gene	Pathway	associated
PA30006	JUN	Gene	Pathway	associated
PA31353	MYC	Gene	Pathway	associated
PA31600	NFKB2	Gene	Pathway	associated
PA33384	PLCB1	Gene	Pathway	associated
PA33385	PLCB2	Gene	Pathway	associated
PA33386	PLCB3	Gene	Pathway	associated
PA33387	PLCB4	Gene	Pathway	associated
PA33388	PLCD1	Gene	Pathway	associated
PA33389	PLCD3	Gene	Pathway	associated
PA33390	PLCD4	Gene	Pathway	associated
PA33391	PLCE1	Gene	Pathway	associated
PA33392	PLCG1	Gene	Pathway	associated		20124951
PA33393	PLCG2	Gene	Pathway	associated		20124951
PA33394	PLCL1	Gene	Pathway	associated
PA33395	PLCL2	Gene	Pathway	associated
PA337	STAT3	Gene	Pathway	associated
PA338	STAT5A	Gene	Pathway	associated
PA34183	RAF1	Gene	Pathway	associated		20124951
PA36042	SP1	Gene	Pathway	associated
PA36183	STAT1	Gene	Pathway	associated
PA36184	STAT2	Gene	Pathway	associated
PA36185	STAT4	Gene	Pathway	associated
PA36186	STAT5B	Gene	Pathway	associated
PA39	ADRB2	Gene	Pathway	associated
PA444522	Hyperglycemia	Disease	ClinicalAnnotation	associated	PD
PA448499	atenolol	Chemical	ClinicalAnnotation	associated	PD
PA449256	dexmedetomidine	Chemical	ClinicalAnnotation	associated

References

Pubmed ID	Year	Title	Citations
36623731	2023	The store-operated Ca(2+) channel Orai1α is required for agonist-evoked NF-κB activation by a mechanism dependent on PKCβ2.	2
36623731	2023	The store-operated Ca(2+) channel Orai1α is required for agonist-evoked NF-κB activation by a mechanism dependent on PKCβ2.	2
34562210	2022	Family-Based Cohort Association Study of PRKCB1, CBLN1 and KCNMB4 Gene Polymorphisms and Autism in Polish Population.	0
34958868	2022	PKC-isoform specific regulation of receptor desensitization and KCNQ1/KCNE1 K(+) channel activity by mutant α(1B)-adrenergic receptors.	0
35027735	2022	PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis.	119
34562210	2022	Family-Based Cohort Association Study of PRKCB1, CBLN1 and KCNMB4 Gene Polymorphisms and Autism in Polish Population.	0
34958868	2022	PKC-isoform specific regulation of receptor desensitization and KCNQ1/KCNE1 K(+) channel activity by mutant α(1B)-adrenergic receptors.	0
35027735	2022	PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis.	119
33561320	2021	PKC-β/Alox5 axis activation promotes Bcr-Abl-independent TKI-resistance in chronic myeloid leukemia.	11
33599293	2021	Dopamine and the phosphorylated dopamine transporter are increased in the diacylglycerol kinase η-knockout mouse brain.	2
34180064	2021	LncRNA VEAL2 regulates PRKCB2 to modulate endothelial permeability in diabetic retinopathy.	22
34198725	2021	Promoter Methylation of PRKCB, ADAMTS12, and NAALAD2 Is Specific to Prostate Cancer and Predicts Biochemical Disease Recurrence.	9
34398388	2021	Therapeutic hypothermia augments the restorative effects of PKC-β and Nox2 inhibition on an in vitro model of human blood-brain barrier.	6
33561320	2021	PKC-β/Alox5 axis activation promotes Bcr-Abl-independent TKI-resistance in chronic myeloid leukemia.	11
33599293	2021	Dopamine and the phosphorylated dopamine transporter are increased in the diacylglycerol kinase η-knockout mouse brain.	2

Citation

Dessen P

PRKCB (protein kinase C beta)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50316/prkcb-(protein-kinase-c-beta)