Identity
HGNC
LOCATION
5q32
LOCUSID
ALIAS
HSPC192,ILFS1,LARS,LEURS,LEUS,LFIS,LRS,PIG44,RNTLS,hr025Cl
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51520
MIM: 151350
HGNC: 6512
Ensembl: ENSG00000133706
Variants:
dbSNP: 51520
ClinVar: 51520
TCGA: ENSG00000133706
COSMIC: LARS1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000133706 | ENST00000274562 | Q9P2J5 |
| ENSG00000133706 | ENST00000394434 | Q9P2J5 |
| ENSG00000133706 | ENST00000510191 | Q9P2J5 |
| ENSG00000133706 | ENST00000674447 | B4DER1 |
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35614056 | 2022 | O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine. | 7 |
| 35962451 | 2022 | Identification of LARS as an essential gene for osteosarcoma proliferation through large-Scale CRISPR-Cas9 screening database and experimental verification. | 6 |
| 35614056 | 2022 | O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine. | 7 |
| 35962451 | 2022 | Identification of LARS as an essential gene for osteosarcoma proliferation through large-Scale CRISPR-Cas9 screening database and experimental verification. | 6 |
| 33300650 | 2021 | Severe course with lethal hepatocellular injury and skeletal muscular dysgenesis in a neonate with infantile liver failure syndrome type 1 caused by novel LARS1 mutations. | 6 |
| 33314043 | 2021 | Infantile Liver Failure Syndrome 1 associated with a novel variant of the LARS1 gene: Clinical, genetic, and functional characterization. | 1 |
| 34325132 | 2021 | Leucyl-tRNA synthetase 1 is required for proliferation of TSC-null cells. | 1 |
| 33300650 | 2021 | Severe course with lethal hepatocellular injury and skeletal muscular dysgenesis in a neonate with infantile liver failure syndrome type 1 caused by novel LARS1 mutations. | 6 |
| 33314043 | 2021 | Infantile Liver Failure Syndrome 1 associated with a novel variant of the LARS1 gene: Clinical, genetic, and functional characterization. | 1 |
| 34325132 | 2021 | Leucyl-tRNA synthetase 1 is required for proliferation of TSC-null cells. | 1 |
| 31780625 | 2020 | Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1. | 35 |
| 32232361 | 2020 | Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond. | 10 |
| 32699352 | 2020 | Genotypic diversity and phenotypic spectrum of infantile liver failure syndrome type 1 due to variants in LARS1. | 9 |
| 31780625 | 2020 | Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1. | 35 |
| 32232361 | 2020 | Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond. | 10 |
Citation
Dessen P
LARS1 (leucyl-tRNA synthetase 1)
Atlas Genet Cytogenet Oncol Haematol. 2008-09-01
Online version: http://atlasgeneticsoncology.org/gene/50329/lars1-(leucyl-trna-synthetase-1)
