ST3GAL6 (ST3 beta-galactoside alpha-2,3-sialyltransferase 6)

2008-09-01  

Identity

HGNC
ST3GAL6
LOCATION
3q12.1
LOCUSID
10402
ALIAS
SIAT10,ST3GALVI
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10402
MIM: 607156
HGNC: 18080
Ensembl: ENSG00000064225

Variants:

dbSNP: 10402
ClinVar: 10402
TCGA: ENSG00000064225
COSMIC: ST3GAL6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000064225ENST00000265261Q9Y274
ENSG00000064225ENST00000394162Q9Y274
ENSG00000064225ENST00000460774C9JWI9
ENSG00000064225ENST00000468553C9JMW7
ENSG00000064225ENST00000469105F2Z2F4
ENSG00000064225ENST00000476833F2Z2F4
ENSG00000064225ENST00000477574C9JXM2
ENSG00000064225ENST00000483910Q9Y274
ENSG00000064225ENST00000485145C9JWJ3
ENSG00000064225ENST00000485391C9IZL6
ENSG00000064225ENST00000486249F2Z2F4
ENSG00000064225ENST00000486334C9J0E2
ENSG00000064225ENST00000492254C9J480
ENSG00000064225ENST00000495376F2Z2F4
ENSG00000064225ENST00000497008C9J9Y4
ENSG00000064225ENST00000497621F8WC98
ENSG00000064225ENST00000613264A0A087WXB8

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGko00601
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGhsa00601
Metabolic pathwaysKEGGhsa01100
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinREACTOMER-HSA-446193
Synthesis of substrates in N-glycan biosythesisREACTOMER-HSA-446219
Sialic acid metabolismREACTOMER-HSA-4085001
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Pre-NOTCH Expression and ProcessingREACTOMER-HSA-1912422
Pre-NOTCH Processing in GolgiREACTOMER-HSA-1912420
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Keratan sulfate/keratin metabolismREACTOMER-HSA-1638074
Keratan sulfate biosynthesisREACTOMER-HSA-2022854

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
336497962021lncRNA ST3GAL6‑AS1 promotes invasion by inhibiting hnRNPA2B1‑mediated ST3GAL6 expression in multiple myeloma.10
336497962021lncRNA ST3GAL6‑AS1 promotes invasion by inhibiting hnRNPA2B1‑mediated ST3GAL6 expression in multiple myeloma.10
319146692020ST3GAL3, ST3GAL4, and ST3GAL6 differ in their regulation of biological functions via the specificities for the α2,3-sialylation of target proteins.29
319146692020ST3GAL3, ST3GAL4, and ST3GAL6 differ in their regulation of biological functions via the specificities for the α2,3-sialylation of target proteins.29
250611762014The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma.67
250611762014The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma.67
211477602011Differences in CD75s- and iso-CD75s-ganglioside content and altered mRNA expression of sialyltransferases ST6GAL1 and ST3GAL6 in human hepatocellular carcinomas and nontumoral liver tissues.11
211477602011Differences in CD75s- and iso-CD75s-ganglioside content and altered mRNA expression of sialyltransferases ST6GAL1 and ST3GAL6 in human hepatocellular carcinomas and nontumoral liver tissues.11
197816612010Differential expression of alpha-2,3-sialyltransferases and alpha-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells.52
205322022010Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes.42
197816612010Differential expression of alpha-2,3-sialyltransferases and alpha-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells.52
205322022010Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes.42
184859152008DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer.43
184859152008DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer.43

Citation

Dessen P

ST3GAL6 (ST3 beta-galactoside alpha-2,3-sialyltransferase 6)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50332/st3gal6-(st3-beta-galactoside-alpha-2-3-sialyltransferase-6)