IRX1 (iroquois homeobox 1)

2008-09-01  

Identity

HGNC
IRX1
LOCATION
5p15.33
LOCUSID
79192
ALIAS
IRX-5,IRXA1

Other Information

Locus ID:

NCBI: 79192
MIM: 606197
HGNC: 14358
Ensembl: ENSG00000170549

Variants:

dbSNP: 79192
ClinVar: 79192
TCGA: ENSG00000170549
COSMIC: IRX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170549ENST00000302006P78414

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
371163642023IRX1 is a novel gene, overexpressed in high-grade IDH-mutant astrocytomas.0
378280252023ADRA2A and IRX1 are putative risk genes for Raynaud's phenomenon.4
371163642023IRX1 is a novel gene, overexpressed in high-grade IDH-mutant astrocytomas.0
378280252023ADRA2A and IRX1 are putative risk genes for Raynaud's phenomenon.4
353286122022The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5 in Acute Myeloid Leukemia.8
353286122022The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5 in Acute Myeloid Leukemia.8
330697832021HOXA9/IRX1 expression pattern defines two subgroups of infant MLL-AF4-driven acute lymphoblastic leukemia.7
330697832021HOXA9/IRX1 expression pattern defines two subgroups of infant MLL-AF4-driven acute lymphoblastic leukemia.7
318461992020Downregulated microRNA-150 upregulates IRX1 to depress proliferation, migration, and invasion, but boost apoptosis of gastric cancer cells.4
322005432020Prognostic value of Iroquois homeobox 1 methylation in non-small cell lung cancers.4
318461992020Downregulated microRNA-150 upregulates IRX1 to depress proliferation, migration, and invasion, but boost apoptosis of gastric cancer cells.4
322005432020Prognostic value of Iroquois homeobox 1 methylation in non-small cell lung cancers.4
308625932019Investigating Role of IRX Family in Development of Female Adolescent Idiopathic Scoliosis: Which One Is Real Cause?2
316404722019IRX1 hypermethylation promotes heart failure by inhibiting CXCL14 expression.5
308625932019Investigating Role of IRX Family in Development of Female Adolescent Idiopathic Scoliosis: Which One Is Real Cause?2

Citation

Dessen P

IRX1 (iroquois homeobox 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50333/irx1-(iroquois-homeobox-1)