PROK2 (prokineticin 2)

2008-09-01  

Identity

HGNC
PROK2
LOCATION
3p13
LOCUSID
60675
ALIAS
BV8,HH4,KAL4,MIT1,PK2

Other Information

Locus ID:

NCBI: 60675
MIM: 607002
HGNC: 18455
Ensembl: ENSG00000163421

Variants:

dbSNP: 60675
ClinVar: 60675
TCGA: ENSG00000163421
COSMIC: PROK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163421ENST00000295619Q9HC23
ENSG00000163421ENST00000353065Q9HC23

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
362181422023Olfactory Neuron Prokineticin-2 as a Potential Target in Parkinson's Disease.6
365390342023Activation of amygdala prokineticin receptor 2 neurons drives the anorexigenic activity of the neuropeptide PK2.3
365495782023Substance P and Prokineticin-2 are overexpressed in olfactory neurons and play differential roles in persons with persistent post-COVID-19 olfactory dysfunction.5
370907212023Bv8 mediates myeloid cell migration and enhances malignancy of colorectal cancer.1
362181422023Olfactory Neuron Prokineticin-2 as a Potential Target in Parkinson's Disease.6
365390342023Activation of amygdala prokineticin receptor 2 neurons drives the anorexigenic activity of the neuropeptide PK2.3
365495782023Substance P and Prokineticin-2 are overexpressed in olfactory neurons and play differential roles in persons with persistent post-COVID-19 olfactory dysfunction.5
370907212023Bv8 mediates myeloid cell migration and enhances malignancy of colorectal cancer.1
359219712022Prokineticin 2 in cancer-related inflammation.9
362637042022PROK2, HRNR, and FIG4 as potential genetic biomarkers of high bleeding propensity in East Asian patients with acute coronary syndrome using ticagrelor.0
359219712022Prokineticin 2 in cancer-related inflammation.9
362637042022PROK2, HRNR, and FIG4 as potential genetic biomarkers of high bleeding propensity in East Asian patients with acute coronary syndrome using ticagrelor.0
331408742021The novel function of miR-3195 for mutant PROK2 (c.223-4C>A) degradation.3
339324862021Pleiotropic effects of prokineticin 2 in the control of energy metabolism.4
342444972021Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury.33

Citation

Dessen P

PROK2 (prokineticin 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50357/prok2-(prokineticin-2)