GLRX3 (glutaredoxin 3)

2008-09-01   Dessen P  

Identity

HGNC
GLRX3
LOCATION
10q26.3
LOCUSID
10539
ALIAS
GLRX4,GRX3,GRX4,PICOT,TXNL2,TXNL3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10539
MIM: 612754
HGNC: 15987
Ensembl: ENSG00000108010

Variants:

dbSNP: 10539
ClinVar: 10539
TCGA: ENSG00000108010
COSMIC: GLRX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108010ENST00000331244O76003
ENSG00000108010ENST00000331244A0A140VJK1
ENSG00000108010ENST00000368644O76003
ENSG00000108010ENST00000368644A0A140VJK1
ENSG00000108010ENST00000481034O76003
ENSG00000108010ENST00000481034A0A140VJK1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
347944022021GLRX3, a novel cancer stem cell-related secretory biomarker of pancreatic ductal adenocarcinoma.3
347944022021GLRX3, a novel cancer stem cell-related secretory biomarker of pancreatic ductal adenocarcinoma.3
324147912020Interactions of GMP with Human Glrx3 and with Saccharomyces cerevisiae Grx3 and Grx4 Converge in the Regulation of the Gcn2 Pathway.4
324296692020GLRX3 Acts as a [2Fe-2S] Cluster Chaperone in the Cytosolic Iron-Sulfur Assembly Machinery Transferring [2Fe-2S] Clusters to NUBP1.9
324147912020Interactions of GMP with Human Glrx3 and with Saccharomyces cerevisiae Grx3 and Grx4 Converge in the Regulation of the Gcn2 Pathway.4
324296692020GLRX3 Acts as a [2Fe-2S] Cluster Chaperone in the Cytosolic Iron-Sulfur Assembly Machinery Transferring [2Fe-2S] Clusters to NUBP1.9
305953802019PICOT binding to the polycomb group protein, EED, alters H3K27 methylation at the MYT1 PRC2 target gene.7
311760192019PICOT (GLRX3) is a positive regulator of stress-induced DNA-damage response.9
315275842019PICOT binding to chromatin-associated EED negatively regulates cyclin D2 expression by increasing H3K27me3 at the CCND2 gene promoter.5
305953802019PICOT binding to the polycomb group protein, EED, alters H3K27 methylation at the MYT1 PRC2 target gene.7
311760192019PICOT (GLRX3) is a positive regulator of stress-induced DNA-damage response.9
315275842019PICOT binding to chromatin-associated EED negatively regulates cyclin D2 expression by increasing H3K27me3 at the CCND2 gene promoter.5
293977912018Glutaredoxin 3 promotes migration and invasion via the Notch signalling pathway in oral squamous cell carcinoma.18
293977912018Glutaredoxin 3 promotes migration and invasion via the Notch signalling pathway in oral squamous cell carcinoma.18
272037422016Glutaredoxin 3 promotes nasopharyngeal carcinoma growth and metastasis via EGFR/Akt pathway and independent of ROS.9

Citation

Dessen P

GLRX3 (glutaredoxin 3)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50374/glrx3-(glutaredoxin-3)