FBXO4 (F-box protein 4)

2008-09-01  

Identity

HGNC
FBXO4
LOCATION
5p13.1
LOCUSID
26272
ALIAS
FBX4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26272
MIM: 609090
HGNC: 13583
Ensembl: ENSG00000151876

Variants:

dbSNP: 26272
ClinVar: 26272
TCGA: ENSG00000151876
COSMIC: FBXO4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151876ENST00000281623Q9UKT5
ENSG00000151876ENST00000296812Q9UKT5
ENSG00000151876ENST00000504463D6REP2
ENSG00000151876ENST00000509134D6RAJ6
ENSG00000151876ENST00000513496D6RAU6

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Association of TriC/CCT with target proteins during biosynthesisREACTOMER-HSA-390471
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

References

Pubmed IDYearTitleCitations
337845092021FBX4 mediates rapid cyclin D1 proteolysis upon DNA damage in immortalized esophageal epithelial cells.2
337845092021FBX4 mediates rapid cyclin D1 proteolysis upon DNA damage in immortalized esophageal epithelial cells.2
287765692017FBXO4 inhibits lung cancer cell survival by targeting Mcl-1 for degradation.13
291422092017Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma.31
287765692017FBXO4 inhibits lung cancer cell survival by targeting Mcl-1 for degradation.13
291422092017Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma.31
247044532014Alternative splicing variants of human Fbx4 disturb cyclin D1 proteolysis in human cancer.10
247044532014Alternative splicing variants of human Fbx4 disturb cyclin D1 proteolysis in human cancer.10
240190692013The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma.20
240190692013The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma.20
212429662011Phosphorylation-dependent regulation of SCF(Fbx4) dimerization and activity involves a novel component, 14-3-3ɛ.23
212429662011Phosphorylation-dependent regulation of SCF(Fbx4) dimerization and activity involves a novel component, 14-3-3ɛ.23
201595922010Structural basis of selective ubiquitination of TRF1 by SCFFbx4.31
201819532010Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase.20
201595922010Structural basis of selective ubiquitination of TRF1 by SCFFbx4.31

Citation

Dessen P

FBXO4 (F-box protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50376/fbxo4-(f-box-protein-4)