NEU1 (neuraminidase 1)

2008-10-01  

Identity

HGNC
LOCATION
6p21.33
LOCUSID
ALIAS
NANH,NEU,SIAL1
FUSION GENES

Other Information

Locus ID:

NCBI: 4758
MIM: 608272
HGNC: 7758
Ensembl: ENSG00000204386

Variants:

dbSNP: 4758
ClinVar: 4758
TCGA: ENSG00000204386
COSMIC: NEU1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204386ENST00000375631Q99519
ENSG00000204386ENST00000375631Q5JQI0
ENSG00000204386ENST00000491768E9PIF4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Other glycan degradationKEGGko00511
Sphingolipid metabolismKEGGko00600
Other glycan degradationKEGGhsa00511
Sphingolipid metabolismKEGGhsa00600
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinREACTOMER-HSA-446193
Synthesis of substrates in N-glycan biosythesisREACTOMER-HSA-446219
Sialic acid metabolismREACTOMER-HSA-4085001
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Glycosphingolipid metabolismREACTOMER-HSA-1660662
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
385058722024HDAC1-Mediated Downregulation of NEU1 Exacerbates the Aggressiveness of Cervical Cancer.0
386638262024Inhibition of neuraminidase-1 sialidase activity by interfering peptides impairs insulin receptor activity in vitro and glucose homeostasis in vivo.0
385058722024HDAC1-Mediated Downregulation of NEU1 Exacerbates the Aggressiveness of Cervical Cancer.0
386638262024Inhibition of neuraminidase-1 sialidase activity by interfering peptides impairs insulin receptor activity in vitro and glucose homeostasis in vivo.0
375114032023Deciphering the Action of Neuraminidase in Glioblastoma Models.1
378447132023Desialylation of ATG5 by sialidase (NEU1) promotes macrophages autophagy and exacerbates inflammation under hypoxia.0
379265732023[The expression of neuraminidase-1 in Ewing sarcoma and its impact on sarcoma cell proliferation and migration].0
375114032023Deciphering the Action of Neuraminidase in Glioblastoma Models.1
378447132023Desialylation of ATG5 by sialidase (NEU1) promotes macrophages autophagy and exacerbates inflammation under hypoxia.0
379265732023[The expression of neuraminidase-1 in Ewing sarcoma and its impact on sarcoma cell proliferation and migration].0
350509272022LOW VULNERABILITY OF THE POSTERIOR EYE SEGMENT TO SARS-COV-2 INFECTION: Chorioretinal SARS-CoV-2 Vulnerability.0
353549052022Selective histone methyltransferase G9a inhibition reduces metastatic development of Ewing sarcoma through the epigenetic regulation of NEU1.11
362327152022PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively via the TLR4/MyD88/NF-κB Signaling Pathway.2
350509272022LOW VULNERABILITY OF THE POSTERIOR EYE SEGMENT TO SARS-COV-2 INFECTION: Chorioretinal SARS-CoV-2 Vulnerability.0
353549052022Selective histone methyltransferase G9a inhibition reduces metastatic development of Ewing sarcoma through the epigenetic regulation of NEU1.11

Citation

Dessen P

NEU1 (neuraminidase 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/50393/neu1-(neuraminidase-1)