Identity
HGNC
LOCATION
19p13.13
LOCUSID
ALIAS
CER2,CERL2,CKTSF1B3,COCO,CRL2,DANTE,GREM3,SP1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 199699
MIM: 609068
HGNC: 26780
Ensembl: ENSG00000179284
Variants:
dbSNP: 199699
ClinVar: 199699
TCGA: ENSG00000179284
COSMIC: DAND5
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000179284 | ENST00000317060 | Q8N907 |
| ENSG00000179284 | ENST00000585548 | K7EQF6 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Developmental Biology | REACTOME | R-HSA-1266738 |
| Signaling by NODAL | REACTOME | R-HSA-1181150 |
| Regulation of signaling by NODAL | REACTOME | R-HSA-1433617 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36316122 | 2022 | A novel biallelic loss-of-function variant in DAND5 causes heterotaxy syndrome. | 0 |
| 36316122 | 2022 | A novel biallelic loss-of-function variant in DAND5 causes heterotaxy syndrome. | 0 |
| 31869685 | 2020 | Generation of a gene-corrected human induced pluripotent stem cell line derived from a patient with laterality defects and congenital heart anomalies with a c.455G > A alteration in DAND5. | 2 |
| 31869685 | 2020 | Generation of a gene-corrected human induced pluripotent stem cell line derived from a patient with laterality defects and congenital heart anomalies with a c.455G > A alteration in DAND5. | 2 |
| 30685069 | 2019 | Reduced levels of Coco in sera of multiple sclerosis patients: A potential role in neuro-regeneration failure. | 3 |
| 30685069 | 2019 | Reduced levels of Coco in sera of multiple sclerosis patients: A potential role in neuro-regeneration failure. | 3 |
| 28738792 | 2017 | Functional study of DAND5 variant in patients with Congenital Heart Disease and laterality defects. | 8 |
| 28738792 | 2017 | Functional study of DAND5 variant in patients with Congenital Heart Disease and laterality defects. | 8 |
| 26908452 | 2016 | The BMP inhibitor DAND5 in serum predicts poor survival in breast cancer. | 6 |
| 26908452 | 2016 | The BMP inhibitor DAND5 in serum predicts poor survival in breast cancer. | 6 |
| 22901808 | 2012 | The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. | 209 |
| 22901808 | 2012 | The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. | 209 |
Citation
Dessen P
DAND5 (DAN domain BMP antagonist family member 5)
Atlas Genet Cytogenet Oncol Haematol. 2008-10-01
Online version: http://atlasgeneticsoncology.org/gene/50397/dand5-(dan-domain-bmp-antagonist-family-member-5)
