APOM (apolipoprotein M)

2008-10-01  

Identity

HGNC
LOCATION
6p21.33
LOCUSID
ALIAS
G3a,HSPC336,NG20,apo-M
FUSION GENES

Other Information

Locus ID:

NCBI: 55937
MIM: 606907
HGNC: 13916
Ensembl: ENSG00000204444

Variants:

dbSNP: 55937
ClinVar: 55937
TCGA: ENSG00000204444
COSMIC: APOM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204444ENST00000375916O95445
ENSG00000204444ENST00000375918Q5SRP5
ENSG00000204444ENST00000375920O95445
ENSG00000204444ENST00000375920A0A1U9X793

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
Retinoid metabolism and transportREACTOMER-HSA-975634
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of fat-soluble vitaminsREACTOMER-HSA-6806667

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
216063632011Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M.156
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
166827452006Isolation and characterization of human apolipoprotein M-containing lipoproteins.51
180065002008Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice.45
146338612003Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels.35
219446992011Plasma levels of sphingosine-1-phosphate and apolipoprotein M in patients with monogenic disorders of HDL metabolism.33
236642372013Liver involvement in sphingosine 1-phosphate dynamism revealed by adenoviral hepatic overexpression of apolipoprotein M.31
278792522017High-Density Lipoprotein-Associated Apolipoprotein M Limits Endothelial Inflammation by Delivering Sphingosine-1-Phosphate to the Sphingosine-1-Phosphate Receptor 1.29
222048622012Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL.28
243188812014Hepatic apolipoprotein M (apoM) overexpression stimulates formation of larger apoM/sphingosine 1-phosphate-enriched plasma high density lipoprotein.28

Citation

Dessen P

APOM (apolipoprotein M)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/50402/apom-(apolipoprotein-m)