Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 11187
MIM: 605561
HGNC: 9025
Ensembl: ENSG00000184363
Variants:
dbSNP: 11187
ClinVar: 11187
TCGA: ENSG00000184363
COSMIC: PKP3
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Developmental Biology | REACTOME | R-HSA-1266738 |
| Keratinization | REACTOME | R-HSA-6805567 |
| Formation of the cornified envelope | REACTOME | R-HSA-6809371 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38048779 | 2024 | Role and function of plakophilin 3 in cancer progression and skin disease. | 1 |
| 38048779 | 2024 | Role and function of plakophilin 3 in cancer progression and skin disease. | 1 |
| 34415821 | 2022 | Disease-related blood-based differential methylation in cystic fibrosis and its representation in lung cancer revealed a regulatory locus in PKP3 in lung epithelial cells. | 0 |
| 34415821 | 2022 | Disease-related blood-based differential methylation in cystic fibrosis and its representation in lung cancer revealed a regulatory locus in PKP3 in lung epithelial cells. | 0 |
| 34058472 | 2021 | A catenin of the plakophilin-subfamily, Pkp3, responds to canonical-Wnt pathway components and signals. | 8 |
| 34260281 | 2021 | Plakophilin 3 and Par3 facilitate desmosomes' association with the apical junctional complex. | 4 |
| 34058472 | 2021 | A catenin of the plakophilin-subfamily, Pkp3, responds to canonical-Wnt pathway components and signals. | 8 |
| 34260281 | 2021 | Plakophilin 3 and Par3 facilitate desmosomes' association with the apical junctional complex. | 4 |
| 30527804 | 2019 | PKP3 interactions with MAPK-JNK-ERK1/2-mTOR pathway regulates autophagy and invasion in ovarian cancer. | 22 |
| 30527804 | 2019 | PKP3 interactions with MAPK-JNK-ERK1/2-mTOR pathway regulates autophagy and invasion in ovarian cancer. | 22 |
| 29146182 | 2018 | Plakophilin3 increases desmosome assembly, size and stability by increasing expression of desmocollin2. | 6 |
| 29678907 | 2018 | 14-3-3 proteins regulate desmosomal adhesion via plakophilins. | 10 |
| 29722422 | 2018 | Expression of plakophilin 3 in diffuse malignant pleural mesothelioma. | 2 |
| 29803740 | 2018 | Plakophilin3 loss leads to an increase in lipocalin2 expression, which is required for tumour formation. | 9 |
| 30144176 | 2018 | Dinitrosopiperazine-decreased PKP3 through upregulating miR-149 participates in nasopharyngeal carcinoma metastasis. | 13 |
Citation
Dessen P
PKP3 (plakophilin 3)
Atlas Genet Cytogenet Oncol Haematol. 2008-10-01
Online version: http://atlasgeneticsoncology.org/gene/50409/pkp3-(plakophilin-3)
