UBE2T (ubiquitin conjugating enzyme E2 T)

2008-10-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
FANCT,HSPC150,PIG50
FUSION GENES

Other Information

Locus ID:

NCBI: 29089
MIM: 610538
HGNC: 25009
Ensembl: ENSG00000077152

Variants:

dbSNP: 29089
ClinVar: 29089
TCGA: ENSG00000077152
COSMIC: UBE2T

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077152ENST00000643045A0A2R8Y812
ENSG00000077152ENST00000646651Q9NPD8
ENSG00000077152ENST00000646651A0A024R9A9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DNA RepairREACTOMER-HSA-73894
Fanconi Anemia PathwayREACTOMER-HSA-6783310
Protein ubiquitinationREACTOMER-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymesREACTOMER-HSA-8866652

References

Pubmed IDYearTitleCitations
386821802024FOXA1/UBE2T Inhibits CD8(+)T Cell Activity by Inducing Mediates Glycolysis in Lung Adenocarcinoma.0
386821802024FOXA1/UBE2T Inhibits CD8(+)T Cell Activity by Inducing Mediates Glycolysis in Lung Adenocarcinoma.0
361563292023UBE2T promotes glioblastoma malignancy through ubiquitination-mediated degradation of RPL6.6
368255872023Diverse roles of UBE2T in cancer (Review).1
371818272023UBE2T Promotes Temozolomide Resistance of Glioblastoma Through Regulating the Wnt/β-Catenin Signaling Pathway.4
373732112023USP15-USP7 Axis and UBE2T Differential Expression May Predict Pathogenesis and Poor Prognosis in De Novo Myelodysplastic Neoplasm.1
361563292023UBE2T promotes glioblastoma malignancy through ubiquitination-mediated degradation of RPL6.6
368255872023Diverse roles of UBE2T in cancer (Review).1
371818272023UBE2T Promotes Temozolomide Resistance of Glioblastoma Through Regulating the Wnt/β-Catenin Signaling Pathway.4
373732112023USP15-USP7 Axis and UBE2T Differential Expression May Predict Pathogenesis and Poor Prognosis in De Novo Myelodysplastic Neoplasm.1
334357872022UBE2T promotes proliferation, invasion and glycolysis of breast cancer cells by regualting the PI3K/AKT signaling pathway.6
345839052022E2F5 promotes proliferation and invasion of gastric cancer through directly upregulating UBE2T transcription.8
351298082022MiR-182-5p inhibits the tumorigenesis of clear cell renal cell carcinoma by repressing UBE2T.6
351301302022UBE2T is upregulated, predicts poor prognosis, and promotes cell proliferation and invasion by promoting epithelial-mesenchymal transition via inhibiting autophagy in an AKT/mTOR dependent manner in ovarian cancer.7
351691252022UBE2T-mediated Akt ubiquitination and Akt/β-catenin activation promotes hepatocellular carcinoma development by increasing pyrimidine metabolism.21

Citation

Dessen P

UBE2T (ubiquitin conjugating enzyme E2 T)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/50427/ube2t-(ubiquitin-conjugating-enzyme-e2-t)