MPRIP (myosin phosphatase Rho interacting protein)

2008-10-01  

Identity

HGNC
LOCATION
17p11.2
LOCUSID
ALIAS
M-RIP,MRIP,RHOIP3,RIP3,p116Rip
FUSION GENES

Other Information

Locus ID:

NCBI: 23164
MIM: 612935
HGNC: 30321
Ensembl: ENSG00000133030

Variants:

dbSNP: 23164
ClinVar: 23164
TCGA: ENSG00000133030
COSMIC: MPRIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133030ENST00000313485H0Y2S9
ENSG00000133030ENST00000341712Q6WCQ1
ENSG00000133030ENST00000395806A8MZF8
ENSG00000133030ENST00000395811Q6WCQ1
ENSG00000133030ENST00000414263H0Y7E2
ENSG00000133030ENST00000429184H7C3G6
ENSG00000133030ENST00000462033K7EL39
ENSG00000133030ENST00000466186A0A1W2PPU9
ENSG00000133030ENST00000577514J3KSK7
ENSG00000133030ENST00000578209J3QRL2
ENSG00000133030ENST00000579361J3QL44
ENSG00000133030ENST00000579832K7EJ14
ENSG00000133030ENST00000584067J3KSW8
ENSG00000133030ENST00000651222A0A494BZV2

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Oncogenic MAPK signalingREACTOMER-HSA-6802957
Signaling by BRAF and RAF fusionsREACTOMER-HSA-6802952

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
249010492014The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury.72
155452842005p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA.24
162579662005M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells.22
212423122011An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers.16
223497012012Association of syntenin-1 with M-RIP polarizes Rac-1 activation during chemotaxis and immune interactions.13
186361742008M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion.6

Citation

Dessen P

MPRIP (myosin phosphatase Rho interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/50434/mprip-(myosin-phosphatase-rho-interacting-protein)