SLC23A2 (solute carrier family 23 member 2)

2008-10-01  

Identity

HGNC
SLC23A2
LOCATION
20p13
LOCUSID
9962
ALIAS
NBTL1,SLC23A1,SVCT2,YSPL2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9962
MIM: 603791
HGNC: 10973
Ensembl: ENSG00000089057

Variants:

dbSNP: 9962
ClinVar: 9962
TCGA: ENSG00000089057
COSMIC: SLC23A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000089057ENST00000338244Q9UGH3
ENSG00000089057ENST00000338244A0A140VK48
ENSG00000089057ENST00000379333Q9UGH3
ENSG00000089057ENST00000379333A0A140VK48
ENSG00000089057ENST00000423430H0Y544

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Vitamin C (ascorbate) metabolismREACTOMER-HSA-196836

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
salivary gland
esophagus
stomach 1
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381820732024Ascorbate and its transporter SVCT2: The dynamic duo's integrated roles in CNS neurobiology and pathophysiology.0
381820732024Ascorbate and its transporter SVCT2: The dynamic duo's integrated roles in CNS neurobiology and pathophysiology.0
373909852023SVCT2/SLC23A2 is a sodium-dependent urate transporter: functional properties and practical application.1
374233232023Nedd4-1 regulates human sodium-dependent vitamin C transporter-2 functional expression in neuronal and epithelial cells.0
373909852023SVCT2/SLC23A2 is a sodium-dependent urate transporter: functional properties and practical application.1
374233232023Nedd4-1 regulates human sodium-dependent vitamin C transporter-2 functional expression in neuronal and epithelial cells.0
354172552022ATRX-dependent SVCT2 mediates macrophage infiltration in the glioblastoma xenograft model.1
363100702022Impact of SLC23A1 and SLC23A2 Polymorphisms on the Risk for Preeclampsia in a Chinese Han Population.0
364364572022SVCT2-mediated ascorbic acid uptake buffers stress responses via DNA hydroxymethylation reprogramming of S100 calcium-binding protein A4 gene.2
354172552022ATRX-dependent SVCT2 mediates macrophage infiltration in the glioblastoma xenograft model.1
363100702022Impact of SLC23A1 and SLC23A2 Polymorphisms on the Risk for Preeclampsia in a Chinese Han Population.0
364364572022SVCT2-mediated ascorbic acid uptake buffers stress responses via DNA hydroxymethylation reprogramming of S100 calcium-binding protein A4 gene.2
334848022021New insights into Vitamin C function: Vitamin C induces JAK2 activation through its receptor-like transporter SVCT2.3
335804602021Role of p53 in transcriptional repression of SVCT2.1
345996502021Limited Association Between Ascorbate Concentrations and Vitamin C Transporters in Renal Cell Carcinoma Cells and Clinical Samples.4

Citation

Dessen P

SLC23A2 (solute carrier family 23 member 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/50440/slc23a2-(solute-carrier-family-23-member-2)