ADAP1 (ArfGAP with dual PH domains 1)

2008-10-01  

Identity

HGNC
LOCATION
7p22.3
LOCUSID
ALIAS
CENTA1,GCS1L,p42IP4
FUSION GENES

Other Information

Locus ID:

NCBI: 11033
MIM: 608114
HGNC: 16486
Ensembl: ENSG00000105963

Variants:

dbSNP: 11033
ClinVar: 11033
TCGA: ENSG00000105963
COSMIC: ADAP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105963ENST00000265846O75689
ENSG00000105963ENST00000435943C9JN36
ENSG00000105963ENST00000437486H7C264
ENSG00000105963ENST00000446141H0Y7Q1
ENSG00000105963ENST00000449296O75689
ENSG00000105963ENST00000453175H7C324
ENSG00000105963ENST00000453823H7C4B3
ENSG00000105963ENST00000454383H7BZT6
ENSG00000105963ENST00000539900O75689
ENSG00000105963ENST00000611167O75689
ENSG00000105963ENST00000617043A0A087WTN6
ENSG00000105963ENST00000649206A0A3B3ISA7

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
194235402009Common variation in genes related to innate immunity and risk of adult glioma.19
146252932004Centaurin-alpha1 is an in vivo phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein for ARF6 that is involved in actin cytoskeleton organization.18
210571102010Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.17
162878132006Centaurin-alpha1 is a phosphatidylinositol 3-kinase-dependent activator of ERK1/2 mitogen-activated protein kinases.12
204069642010Risk of meningioma and common variation in genes related to innate immunity.12
157784542005Centaurin-alpha 1, an ADP-ribosylation factor 6 GTPase activating protein, inhibits beta 2-adrenoceptor internalization.8
156791002004The arf6 GAP centaurin alpha-1 is a neuronal actin-binding protein which also functions via GAP-independent activity to regulate the actin cytoskeleton.7
168058302006Interaction of the brain-specific protein p42IP4/centaurin-alpha1 with the peptidase nardilysin is regulated by the cognate ligands of p42IP4, PtdIns(3,4,5)P3 and Ins(1,3,4,5)P4, with stereospecificity.7
151068472004Altered expression of protein p42IP4/centaurin-alpha 1 in Alzheimer's disease brains and possible interaction of p42IP4 with nucleolin.6
182986632008RanBPM, a novel interaction partner of the brain-specific protein p42IP4/centaurin alpha-1.6

Citation

Dessen P

ADAP1 (ArfGAP with dual PH domains 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/50453/adap1-(arfgap-with-dual-ph-domains-1)