Identity
HGNC
LOCATION
1q32.3
LOCUSID
ALIAS
CDT2,DCAF2,L2DTL,RAMP
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51514
MIM: 610617
HGNC: 30288
Ensembl: ENSG00000143476
Variants:
dbSNP: 51514
ClinVar: 51514
TCGA: ENSG00000143476
COSMIC: DTL
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000143476 | ENST00000366991 | Q9NZJ0 |
| ENSG00000143476 | ENST00000542077 | F5GZ90 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| DNA Repair | REACTOME | R-HSA-73894 |
| DNA Damage Bypass | REACTOME | R-HSA-73893 |
| Recognition of DNA damage by PCNA-containing replication complex | REACTOME | R-HSA-110314 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37968553 | 2024 | Regular or DCAF2: How CRL4(DCAF2) Affects IBD-Related Mucosal Injury. | 0 |
| 37968554 | 2024 | Epithelial CRL4(DCAF2) Is Critical for Maintaining Intestinal Homeostasis Against DSS-Induced Colitis by Regulating the Proliferation and Repair of Intestinal Epithelial Cells. | 0 |
| 37968553 | 2024 | Regular or DCAF2: How CRL4(DCAF2) Affects IBD-Related Mucosal Injury. | 0 |
| 37968554 | 2024 | Epithelial CRL4(DCAF2) Is Critical for Maintaining Intestinal Homeostasis Against DSS-Induced Colitis by Regulating the Proliferation and Repair of Intestinal Epithelial Cells. | 0 |
| 37171007 | 2023 | DTL is a Novel Downstream Gene of E2F1 that Promotes the Progression of Hepatocellular Carcinoma. | 1 |
| 37522575 | 2023 | Circ-DTL sponges miR-758-3p to accelerate cervical cancer malignant progression by regulating DCUN1D1 expression. | 0 |
| 37171007 | 2023 | DTL is a Novel Downstream Gene of E2F1 that Promotes the Progression of Hepatocellular Carcinoma. | 1 |
| 37522575 | 2023 | Circ-DTL sponges miR-758-3p to accelerate cervical cancer malignant progression by regulating DCUN1D1 expression. | 0 |
| 35103094 | 2022 | DTL Is a Prognostic Biomarker and Promotes Bladder Cancer Progression through Regulating the AKT/mTOR axis. | 11 |
| 35392073 | 2022 | Role of DTL in Hepatocellular Carcinoma and Its Impact on the Tumor Microenvironment. | 6 |
| 35840896 | 2022 | miR-34a negatively regulates cell cycle factor Cdt2/DTL in HPV infected cervical cancer cells. | 3 |
| 35103094 | 2022 | DTL Is a Prognostic Biomarker and Promotes Bladder Cancer Progression through Regulating the AKT/mTOR axis. | 11 |
| 35392073 | 2022 | Role of DTL in Hepatocellular Carcinoma and Its Impact on the Tumor Microenvironment. | 6 |
| 35840896 | 2022 | miR-34a negatively regulates cell cycle factor Cdt2/DTL in HPV infected cervical cancer cells. | 3 |
| 33627782 | 2021 | CRL4A(DTL) degrades DNA-PKcs to modulate NHEJ repair and induce genomic instability and subsequent malignant transformation. | 12 |
Citation
Dessen P
DTL (denticleless E3 ubiquitin protein ligase homolog)
Atlas Genet Cytogenet Oncol Haematol. 2008-10-01
Online version: http://atlasgeneticsoncology.org/gene/50456/dtl-(denticleless-e3-ubiquitin-protein-ligase-homolog)
