Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9575
MIM: 601851
HGNC: 2082
Ensembl: ENSG00000134852
Variants:
dbSNP: 9575
ClinVar: 9575
TCGA: ENSG00000134852
COSMIC: CLOCK
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000134852 | ENST00000309964 | O15516 |
| ENSG00000134852 | ENST00000381322 | O15516 |
| ENSG00000134852 | ENST00000435527 | C9JK03 |
| ENSG00000134852 | ENST00000513440 | O15516 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443450 | Asthma | Disease | ClinicalAnnotation | associated | PD | 23508266 | |
| PA447199 | Bipolar Disorder | Disease | ClinicalAnnotation | associated | PD | 21047205 | |
| PA448068 | salbutamol | Chemical | ClinicalAnnotation | associated | PD | 23508266 | |
| PA450243 | lithium | Chemical | ClinicalAnnotation | associated | PD | 21047205 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38338765 | 2024 | Mucosal Genes Encoding Clock, Inflammation and Their Mutual Regulators Are Disrupted in Pediatric Patients with Active Ulcerative Colitis. | 0 |
| 38492220 | 2024 | YTHDF1-CLOCK axis contributes to pathogenesis of allergic airway inflammation through LLPS. | 0 |
| 38676534 | 2024 | CLOCK gene circannual expression in cluster headache. | 0 |
| 38805270 | 2024 | Phosphorylation of DNA-binding domains of CLOCK-BMAL1 complex for PER-dependent inhibition in circadian clock of mammalian cells. | 0 |
| 38338765 | 2024 | Mucosal Genes Encoding Clock, Inflammation and Their Mutual Regulators Are Disrupted in Pediatric Patients with Active Ulcerative Colitis. | 0 |
| 38492220 | 2024 | YTHDF1-CLOCK axis contributes to pathogenesis of allergic airway inflammation through LLPS. | 0 |
| 38676534 | 2024 | CLOCK gene circannual expression in cluster headache. | 0 |
| 38805270 | 2024 | Phosphorylation of DNA-binding domains of CLOCK-BMAL1 complex for PER-dependent inhibition in circadian clock of mammalian cells. | 0 |
| 36595671 | 2023 | Circadian regulator BMAL1::CLOCK promotes cell proliferation in hepatocellular carcinoma by controlling apoptosis and cell cycle. | 25 |
| 36646788 | 2023 | Nucleus-exported CLOCK acetylates PRPS to promote de novo nucleotide synthesis and liver tumour growth. | 4 |
| 36789957 | 2023 | [Prevalence of the GA risk haplotype of the rs1554483 and rs4864548 polymorphisms of the CLOCK gene associated with obesity and overweight in 26 populations]. | 0 |
| 36795563 | 2023 | Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma. | 17 |
| 36847953 | 2023 | Clock 3111 T/C and Period3 VNTR gene polymorphisms and proteins, and melatonin levels in women with infertility. | 0 |
| 36897197 | 2023 | Novel CLOCK and NR1D2 variants in 64 sighted Japanese individuals with non-24-hour sleep-wake rhythm disorder. | 0 |
| 37036639 | 2023 | Relationship Between Breast Cancer Risk and Polymorphisms in CLOCK Gene: A Systematic Review and Meta-Analysis. | 0 |
Citation
Dessen P
CLOCK (clock circadian regulator)
Atlas Genet Cytogenet Oncol Haematol. 2008-12-01
Online version: http://atlasgeneticsoncology.org/gene/50468/clock-(clock-circadian-regulator)
