SLIT1 (slit guidance ligand 1)

2008-12-01  

Identity

HGNC
SLIT1
LOCATION
10q24.1
LOCUSID
6585
ALIAS
MEGF4,SLIL1,SLIT-1,SLIT3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6585
MIM: 603742
HGNC: 11085
Ensembl: ENSG00000187122

Variants:

dbSNP: 6585
ClinVar: 6585
TCGA: ENSG00000187122
COSMIC: SLIT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187122ENST00000266058O75093
ENSG00000187122ENST00000314867Q5T0V4
ENSG00000187122ENST00000371041Q5T0V2
ENSG00000187122ENST00000371070Q5T0V0

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447288Essential hypertensionDiseaseClinicalAnnotationassociatedPD
PA449552etoposideChemicalClinicalAnnotationassociatedPKPD
PA449899hydrochlorothiazideChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
359965102022Micro RNA-640 Targeting SLIT1 Enhances Glioma Radiosensitivity by Restraining the Activation of Wnt/β-Catenin Signaling Pathway.2
359965102022Micro RNA-640 Targeting SLIT1 Enhances Glioma Radiosensitivity by Restraining the Activation of Wnt/β-Catenin Signaling Pathway.2
311864932019Clonal hematopoiesis by SLIT1-mutated hematopoietic stem cells due to a breakdown of the autocrine loop involving Slit1 in acquired aplastic anemia.2
311864932019Clonal hematopoiesis by SLIT1-mutated hematopoietic stem cells due to a breakdown of the autocrine loop involving Slit1 in acquired aplastic anemia.2
294581432018SUV39H2 promotes colorectal cancer proliferation and metastasis via tri-methylation of the SLIT1 promoter.25
294581432018SUV39H2 promotes colorectal cancer proliferation and metastasis via tri-methylation of the SLIT1 promoter.25
188295372008SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium.73
188295372008SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium.73
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.83
168405502006Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits.36
170625602006A molecular mechanism for the heparan sulfate dependence of slit-robo signaling.61
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.83
168405502006Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits.36
170625602006A molecular mechanism for the heparan sulfate dependence of slit-robo signaling.61
161626492005Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain.40

Citation

Dessen P

SLIT1 (slit guidance ligand 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50488/slit1-(slit-guidance-ligand-1)