Identity
HGNC
LOCATION
10q24.1
LOCUSID
ALIAS
MEGF4,SLIL1,SLIT-1,SLIT3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6585
MIM: 603742
HGNC: 11085
Ensembl: ENSG00000187122
Variants:
dbSNP: 6585
ClinVar: 6585
TCGA: ENSG00000187122
COSMIC: SLIT1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000187122 | ENST00000266058 | O75093 |
| ENSG00000187122 | ENST00000314867 | Q5T0V4 |
| ENSG00000187122 | ENST00000371041 | Q5T0V2 |
| ENSG00000187122 | ENST00000371070 | Q5T0V0 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Axon guidance | KEGG | ko04360 |
| Axon guidance | KEGG | hsa04360 |
| Developmental Biology | REACTOME | R-HSA-1266738 |
| Axon guidance | REACTOME | R-HSA-422475 |
| Netrin-1 signaling | REACTOME | R-HSA-373752 |
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447288 | Essential hypertension | Disease | ClinicalAnnotation | associated | PD | ||
| PA449552 | etoposide | Chemical | ClinicalAnnotation | associated | PK | PD | |
| PA449899 | hydrochlorothiazide | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35996510 | 2022 | Micro RNA-640 Targeting SLIT1 Enhances Glioma Radiosensitivity by Restraining the Activation of Wnt/β-Catenin Signaling Pathway. | 2 |
| 35996510 | 2022 | Micro RNA-640 Targeting SLIT1 Enhances Glioma Radiosensitivity by Restraining the Activation of Wnt/β-Catenin Signaling Pathway. | 2 |
| 31186493 | 2019 | Clonal hematopoiesis by SLIT1-mutated hematopoietic stem cells due to a breakdown of the autocrine loop involving Slit1 in acquired aplastic anemia. | 2 |
| 31186493 | 2019 | Clonal hematopoiesis by SLIT1-mutated hematopoietic stem cells due to a breakdown of the autocrine loop involving Slit1 in acquired aplastic anemia. | 2 |
| 29458143 | 2018 | SUV39H2 promotes colorectal cancer proliferation and metastasis via tri-methylation of the SLIT1 promoter. | 25 |
| 29458143 | 2018 | SUV39H2 promotes colorectal cancer proliferation and metastasis via tri-methylation of the SLIT1 promoter. | 25 |
| 18829537 | 2008 | SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium. | 73 |
| 18829537 | 2008 | SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium. | 73 |
| 16385451 | 2006 | A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. | 83 |
| 16840550 | 2006 | Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits. | 36 |
| 17062560 | 2006 | A molecular mechanism for the heparan sulfate dependence of slit-robo signaling. | 61 |
| 16385451 | 2006 | A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. | 83 |
| 16840550 | 2006 | Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits. | 36 |
| 17062560 | 2006 | A molecular mechanism for the heparan sulfate dependence of slit-robo signaling. | 61 |
| 16162649 | 2005 | Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain. | 40 |
Citation
Dessen P
SLIT1 (slit guidance ligand 1)
Atlas Genet Cytogenet Oncol Haematol. 2008-12-01
Online version: http://atlasgeneticsoncology.org/gene/50488/slit1-(slit-guidance-ligand-1)
