STX1A (syntaxin 1A)

2008-12-01  

Identity

HGNC
LOCATION
7q11.23
LOCUSID
ALIAS
HPC-1,P35-1,STX1,SYN1A

Other Information

Locus ID:

NCBI: 6804
MIM: 186590
HGNC: 11433
Ensembl: ENSG00000106089

Variants:

dbSNP: 6804
ClinVar: 6804
TCGA: ENSG00000106089
COSMIC: STX1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106089ENST00000222812Q16623
ENSG00000106089ENST00000222812Q75ME0
ENSG00000106089ENST00000395154A8MZ54
ENSG00000106089ENST00000395155A0A0C4DFZ1
ENSG00000106089ENST00000395156Q16623

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
SNARE interactions in vesicular transportKEGGko04130
SNARE interactions in vesicular transportKEGGhsa04130
Synaptic vesicle cycleKEGGko04721
Synaptic vesicle cycleKEGGhsa04721
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
Insulin secretionKEGGhsa04911
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Release CycleREACTOMER-HSA-112310
Norepinephrine Neurotransmitter Release CycleREACTOMER-HSA-181430
Serotonin Neurotransmitter Release CycleREACTOMER-HSA-181429
Glutamate Neurotransmitter Release CycleREACTOMER-HSA-210500
Dopamine Neurotransmitter Release CycleREACTOMER-HSA-212676
Acetylcholine Neurotransmitter Release CycleREACTOMER-HSA-264642
GABA synthesis, release, reuptake and degradationREACTOMER-HSA-888590
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Uptake and actions of bacterial toxinsREACTOMER-HSA-5339562
Neurotoxicity of clostridium toxinsREACTOMER-HSA-168799
Toxicity of botulinum toxin type C (BoNT/C)REACTOMER-HSA-5250971
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Developmental BiologyREACTOMER-HSA-1266738
LGI-ADAM interactionsREACTOMER-HSA-5682910
Protein-protein interactions at synapsesREACTOMER-HSA-6794362
Interactions of neurexins and neuroligins at synapsesREACTOMER-HSA-6794361

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
180657282007Three-gene prognostic classifier for early-stage non small-cell lung cancer.82
172640802007Functionally and spatially distinct modes of munc18-syntaxin 1 interaction.55
152027722004Syntaxin 1A and receptor for activated C kinase interact with the N-terminal region of human dopamine transporter.43
195578572009De novo STXBP1 mutations in mental retardation and nonsyndromic epilepsy.42
204710302010Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.42
190048282009Direct interaction of otoferlin with syntaxin 1A, SNAP-25, and the L-type voltage-gated calcium channel Cav1.3.40
221306602012A Ca(v)3.2/syntaxin-1A signaling complex controls T-type channel activity and low-threshold exocytosis.40
222645122012The Legionella pneumophila effector DrrA is sufficient to stimulate SNARE-dependent membrane fusion.35
227912902012Munc18b/STXBP2 is required for platelet secretion.34
242185702013Prefusion structure of syntaxin-1A suggests pathway for folding into neuronal trans-SNARE complex fusion intermediate.31

Citation

Dessen P

STX1A (syntaxin 1A)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50519/stx1a-(syntaxin-1a)