STX1A (syntaxin 1A)

2008-12-01  

Identity

HGNC
LOCATION
7q11.23
LOCUSID
ALIAS
HPC-1,P35-1,STX1,SYN1A

Other Information

Locus ID:

NCBI: 6804
MIM: 186590
HGNC: 11433
Ensembl: ENSG00000106089

Variants:

dbSNP: 6804
ClinVar: 6804
TCGA: ENSG00000106089
COSMIC: STX1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106089ENST00000222812Q16623
ENSG00000106089ENST00000222812Q75ME0
ENSG00000106089ENST00000395154A8MZ54
ENSG00000106089ENST00000395155A0A0C4DFZ1
ENSG00000106089ENST00000395156Q16623

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
SNARE interactions in vesicular transportKEGGko04130
SNARE interactions in vesicular transportKEGGhsa04130
Synaptic vesicle cycleKEGGko04721
Synaptic vesicle cycleKEGGhsa04721
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
Insulin secretionKEGGhsa04911
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Release CycleREACTOMER-HSA-112310
Norepinephrine Neurotransmitter Release CycleREACTOMER-HSA-181430
Serotonin Neurotransmitter Release CycleREACTOMER-HSA-181429
Glutamate Neurotransmitter Release CycleREACTOMER-HSA-210500
Dopamine Neurotransmitter Release CycleREACTOMER-HSA-212676
Acetylcholine Neurotransmitter Release CycleREACTOMER-HSA-264642
GABA synthesis, release, reuptake and degradationREACTOMER-HSA-888590
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Uptake and actions of bacterial toxinsREACTOMER-HSA-5339562
Neurotoxicity of clostridium toxinsREACTOMER-HSA-168799
Toxicity of botulinum toxin type C (BoNT/C)REACTOMER-HSA-5250971
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Developmental BiologyREACTOMER-HSA-1266738
LGI-ADAM interactionsREACTOMER-HSA-5682910
Protein-protein interactions at synapsesREACTOMER-HSA-6794362
Interactions of neurexins and neuroligins at synapsesREACTOMER-HSA-6794361

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382614102024Syntaxin1A overexpression and pain insensitivity in individuals with 7q11.23 duplication syndrome.0
386152012024Assessment of Stx-1A gene polymorphism (rs1569061) in relation to the development of multiple sclerosis in Egyptian patients.0
382614102024Syntaxin1A overexpression and pain insensitivity in individuals with 7q11.23 duplication syndrome.0
386152012024Assessment of Stx-1A gene polymorphism (rs1569061) in relation to the development of multiple sclerosis in Egyptian patients.0
365645382023Heterozygous and homozygous variants in STX1A cause a neurodevelopmental disorder with or without epilepsy.5
365645382023Heterozygous and homozygous variants in STX1A cause a neurodevelopmental disorder with or without epilepsy.5
332175622021Oligomeric α-Syn and SNARE complex proteins in peripheral extracellular vesicles of neural origin are biomarkers for Parkinson's disease.38
347648222021Syntaxin-1 and Insulinoma-Associated Protein 1 Expression in Breast Neoplasms with Neuroendocrine Features.2
332175622021Oligomeric α-Syn and SNARE complex proteins in peripheral extracellular vesicles of neural origin are biomarkers for Parkinson's disease.38
347648222021Syntaxin-1 and Insulinoma-Associated Protein 1 Expression in Breast Neoplasms with Neuroendocrine Features.2
320593622020Syntaxin 1: A Novel Robust Immunophenotypic Marker of Neuroendocrine Tumors.1
328152822020De novo STXBP1 mutation in a child with developmental delay and spasticity reveals a major structural alteration in the interface with syntaxin 1A.4
320593622020Syntaxin 1: A Novel Robust Immunophenotypic Marker of Neuroendocrine Tumors.1
328152822020De novo STXBP1 mutation in a child with developmental delay and spasticity reveals a major structural alteration in the interface with syntaxin 1A.4
309169962019Membrane-mediated disorder-to-order transition of SNAP25 flexible linker facilitates its interaction with syntaxin-1 and SNARE-complex assembly.5

Citation

Dessen P

STX1A (syntaxin 1A)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50519/stx1a-(syntaxin-1a)