SCG3 (secretogranin III)

2008-12-01  

Identity

HGNC
SCG3
LOCATION
15q21.2
LOCUSID
29106
ALIAS
SGIII
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29106
MIM: 611796
HGNC: 13707
Ensembl: ENSG00000104112

Variants:

dbSNP: 29106
ClinVar: 29106
TCGA: ENSG00000104112
COSMIC: SCG3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104112ENST00000220478Q8WXD2
ENSG00000104112ENST00000542355Q8WXD2
ENSG00000104112ENST00000558709H0YKC2

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
340627332021Concurrent Physiological and Pathological Angiogenesis in Retinopathy of Prematurity and Emerging Therapies.20
342575452021SCG3 Protein Expression in Glioma Associates With less Malignancy and Favorable Clinical Outcomes.2
340627332021Concurrent Physiological and Pathological Angiogenesis in Retinopathy of Prematurity and Emerging Therapies.20
342575452021SCG3 Protein Expression in Glioma Associates With less Malignancy and Favorable Clinical Outcomes.2
288563812018Secretogranin III: a diabetic retinopathy-selective angiogenic factor.16
302801902018Secretogranin III may be an indicator of paraquat-induced astrocyte activation and affects the recruitment of BDNF during this process.2
288563812018Secretogranin III: a diabetic retinopathy-selective angiogenic factor.16
302801902018Secretogranin III may be an indicator of paraquat-induced astrocyte activation and affects the recruitment of BDNF during this process.2
289491412017Glycobiomarker, Fucosylated Short-Form Secretogranin III Levels Are Increased in Serum of Patients with Small Cell Lung Carcinoma.9
289491412017Glycobiomarker, Fucosylated Short-Form Secretogranin III Levels Are Increased in Serum of Patients with Small Cell Lung Carcinoma.9
248826222014The oncoprotein HBXIP up-regulates SCG3 through modulating E2F1 and miR-509-3p in hepatoma cells.15
248826222014The oncoprotein HBXIP up-regulates SCG3 through modulating E2F1 and miR-509-3p in hepatoma cells.15
229980352013Secretory sorting receptors carboxypeptidase E and secretogranin III in amyloid β-associated neural degeneration in Alzheimer's disease.27
229980352013Secretory sorting receptors carboxypeptidase E and secretogranin III in amyloid β-associated neural degeneration in Alzheimer's disease.27
229877612012Dysregulated expression of secretogranin III is involved in neurotoxin-induced dopaminergic neuron apoptosis.13

Citation

Dessen P

SCG3 (secretogranin III)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50553/img/deep-insight-explorer/humanGenome