SCG3 (secretogranin III)

2008-12-01  

Identity

HGNC
LOCATION
15q21.2
LOCUSID
ALIAS
SGIII
FUSION GENES

Other Information

Locus ID:

NCBI: 29106
MIM: 611796
HGNC: 13707
Ensembl: ENSG00000104112

Variants:

dbSNP: 29106
ClinVar: 29106
TCGA: ENSG00000104112
COSMIC: SCG3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104112ENST00000220478Q8WXD2
ENSG00000104112ENST00000542355Q8WXD2
ENSG00000104112ENST00000558709H0YKC2

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
217961372011Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population.21
229980352013Secretory sorting receptors carboxypeptidase E and secretogranin III in amyloid β-associated neural degeneration in Alzheimer's disease.13
184481762008Measurements of secretogranins II, III, V and proconvertases 1/3 and 2 in plasma from patients with neuroendocrine tumours.12
248826222014The oncoprotein HBXIP up-regulates SCG3 through modulating E2F1 and miR-509-3p in hepatoma cells.10
172001732007Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity.8
172001732007Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity.8
205509512010Secretogranin III in human neuroendocrine tumours: a comparative immunohistochemical study with chromogranins A and B and secretogranin II.8
229877612012Dysregulated expression of secretogranin III is involved in neurotoxin-induced dopaminergic neuron apoptosis.6
289491412017Glycobiomarker, Fucosylated Short-Form Secretogranin III Levels Are Increased in Serum of Patients with Small Cell Lung Carcinoma.6
210464542010Immunohistochemical and biochemical studies with region-specific antibodies to chromogranins A and B and secretogranins II and III in neuroendocrine tumors.5

Citation

Dessen P

SCG3 (secretogranin III)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50553/scg3-(secretogranin-iii)