PRPF6 (pre-mRNA processing factor 6)

2008-12-01  

Identity

HGNC
LOCATION
20q13.33
LOCUSID
ALIAS
ANT-1,ANT1,C20orf14,Prp6,RP60,SNRNP102,TOM,U5-102K,hPrp6
FUSION GENES

Other Information

Locus ID:

NCBI: 24148
MIM: 613979
HGNC: 15860
Ensembl: ENSG00000101161

Variants:

dbSNP: 24148
ClinVar: 24148
TCGA: ENSG00000101161
COSMIC: PRPF6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101161ENST00000266079O94906

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Spliceosome, U4/U6.U5 tri-snRNPKEGGhsa_M00354
Spliceosome, U4/U6.U5 tri-snRNPKEGGM00354
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA Splicing - Minor PathwayREACTOMER-HSA-72165

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381394382023Pathogenic Variants in USH1G/SANS Alter Protein Interaction with Pre-RNA Processing Factors PRPF6 and PRPF31 of the Spliceosome.0
381394382023Pathogenic Variants in USH1G/SANS Alter Protein Interaction with Pre-RNA Processing Factors PRPF6 and PRPF31 of the Spliceosome.0
333908432021PRPF6 promotes androgen receptor/androgen receptor-variant 7 actions in castration-resistant prostate cancer cells.8
373039392021PRPF6 promotes metastasis and paclitaxel resistance of ovarian cancer via SNHG16/CEBPB/GATA3 axis.1
333908432021PRPF6 promotes androgen receptor/androgen receptor-variant 7 actions in castration-resistant prostate cancer cells.8
373039392021PRPF6 promotes metastasis and paclitaxel resistance of ovarian cancer via SNHG16/CEBPB/GATA3 axis.1
327453182020Splicing factor PRPF6 upregulates oncogenic androgen receptor signaling pathway in hepatocellular carcinoma.9
327453182020Splicing factor PRPF6 upregulates oncogenic androgen receptor signaling pathway in hepatocellular carcinoma.9
247880922014An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth.53
247880922014An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth.53
215493382011A missense mutation in PRPF6 causes impairment of pre-mRNA splicing and autosomal-dominant retinitis pigmentosa.62
215493382011A missense mutation in PRPF6 causes impairment of pre-mRNA splicing and autosomal-dominant retinitis pigmentosa.62
201189382010Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation.45
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.37
201189382010Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation.45

Citation

Dessen P

PRPF6 (pre-mRNA processing factor 6)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50576/prpf6-(pre-mrna-processing-factor-6)