SNAP23 (synaptosome associated protein 23)

2008-12-01  

Identity

HGNC
SNAP23
LOCATION
15q15.1
LOCUSID
8773
ALIAS
HsT17016,SNAP-23,SNAP23A,SNAP23B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8773
MIM: 602534
HGNC: 11131
Ensembl: ENSG00000092531

Variants:

dbSNP: 8773
ClinVar: 8773
TCGA: ENSG00000092531
COSMIC: SNAP23

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000092531ENST00000249647O00161
ENSG00000092531ENST00000249647A8K287
ENSG00000092531ENST00000349777O00161
ENSG00000092531ENST00000349777A0A024R9R8
ENSG00000092531ENST00000397138O00161
ENSG00000092531ENST00000397138A0A024R9R8
ENSG00000092531ENST00000561526H3BM38
ENSG00000092531ENST00000563765H3BU94
ENSG00000092531ENST00000563830H3BQY9
ENSG00000092531ENST00000563873H3BR99
ENSG00000092531ENST00000564153H3BPJ0
ENSG00000092531ENST00000566035H3BNG6
ENSG00000092531ENST00000566327H3BV99
ENSG00000092531ENST00000567094H3BNE1
ENSG00000092531ENST00000568331H3BNE1
ENSG00000092531ENST00000568451H3BNE1
ENSG00000092531ENST00000568841H3BP15
ENSG00000092531ENST00000568859H3BR18
ENSG00000092531ENST00000626061H3BU94
ENSG00000092531ENST00000627440H3BNG6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SNARE interactions in vesicular transportKEGGko04130
SNARE interactions in vesicular transportKEGGhsa04130
Platelet activationKEGGhsa04611
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
ER-Phagosome pathwayREACTOMER-HSA-1236974
Innate Immune SystemREACTOMER-HSA-168249
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365279302023SNAP23 is essential for germination of EV-D68 replication organelles.0
370869612023Tumor-derived extracellular vesicles delivering TNF-α promotes colorectal cancer metastasis via the NF-kB/LAMB3/AKT axis by targeting SNAP23.2
378858782023Syntaxin-4 and SNAP23 are involved in neutrophil degranulation, but not in the release of mitochondrial DNA during NET formation.0
365279302023SNAP23 is essential for germination of EV-D68 replication organelles.0
370869612023Tumor-derived extracellular vesicles delivering TNF-α promotes colorectal cancer metastasis via the NF-kB/LAMB3/AKT axis by targeting SNAP23.2
378858782023Syntaxin-4 and SNAP23 are involved in neutrophil degranulation, but not in the release of mitochondrial DNA during NET formation.0
361845182022SNAP23-Mediated Perturbation of Cholesterol-Enriched Membrane Microdomain Promotes Extracellular Vesicle Production in Src-Activated Cancer Cells.3
361845182022SNAP23-Mediated Perturbation of Cholesterol-Enriched Membrane Microdomain Promotes Extracellular Vesicle Production in Src-Activated Cancer Cells.3
329496472021IKKβ activation promotes amphisome formation and extracellular vesicle secretion in tumor cells.13
332132782021Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes.10
334462212021Let-7a regulates EV secretion and mitochondrial oxidative phosphorylation by targeting SNAP23 in colorectal cancer.14
340883372021LINC00511 drives invasive behavior in hepatocellular carcinoma by regulating exosome secretion and invadopodia formation.22
329496472021IKKβ activation promotes amphisome formation and extracellular vesicle secretion in tumor cells.13
332132782021Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes.10
334462212021Let-7a regulates EV secretion and mitochondrial oxidative phosphorylation by targeting SNAP23 in colorectal cancer.14

Citation

Dessen P

SNAP23 (synaptosome associated protein 23)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50583/snap23-(synaptosome-associated-protein-23)