DOCK10 (dedicator of cytokinesis 10)

2008-12-01  

Identity

HGNC
LOCATION
2q36.2
LOCUSID
ALIAS
DRIP2,Nbla10300,ZIZ3
FUSION GENES

Other Information

Locus ID:

NCBI: 55619
MIM: 611518
HGNC: 23479
Ensembl: ENSG00000135905

Variants:

dbSNP: 55619
ClinVar: 55619
TCGA: ENSG00000135905
COSMIC: DOCK10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135905ENST00000258390Q96BY6
ENSG00000135905ENST00000409592Q96BY6
ENSG00000135905ENST00000422684H7C0I3
ENSG00000135905ENST00000435582F8WE73
ENSG00000135905ENST00000458608F8WB48
ENSG00000135905ENST00000535663H0YFC5
ENSG00000135905ENST00000644695A0A2R8Y5U0
ENSG00000135905ENST00000645028A0A2R8YD85

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
188351692008DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells.77
184992582008Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes.15
215143402011Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes.7
307282922019ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation.7

Citation

Dessen P

DOCK10 (dedicator of cytokinesis 10)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50586/dock10-(dedicator-of-cytokinesis-10)