SEMA3D (semaphorin 3D)

2008-12-01  

Identity

HGNC
SEMA3D
LOCATION
7q21.11
LOCUSID
223117
ALIAS
Sema-Z2,coll-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 223117
MIM: 609907
HGNC: 10726
Ensembl: ENSG00000153993

Variants:

dbSNP: 223117
ClinVar: 223117
TCGA: ENSG00000153993
COSMIC: SEMA3D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153993ENST00000284136O95025
ENSG00000153993ENST00000444867C9JYT6

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
372194902023Tumor-derived semaphorin 3D promoting cancer cachexia via regulating hypothalamic pro-opiomelanocortin neurons.0
372194902023Tumor-derived semaphorin 3D promoting cancer cachexia via regulating hypothalamic pro-opiomelanocortin neurons.0
351909282022Semaphorin 3D inhibits proliferation and migration of papillary thyroid carcinoma by regulating MAPK/ERK signaling pathway.3
351909282022Semaphorin 3D inhibits proliferation and migration of papillary thyroid carcinoma by regulating MAPK/ERK signaling pathway.3
278768152017Variable expressivity and genetic heterogeneity involving DPT and SEMA3D genes in autosomal dominant familial Meniere's disease.28
283204752017Decreased expression of semaphorin 3D is associated with genesis and development in colorectal cancer.8
290749882017Promoter-level transcriptome in primary lesions of endometrial cancer identified biomarkers associated with lymph node metastasis.7
278768152017Variable expressivity and genetic heterogeneity involving DPT and SEMA3D genes in autosomal dominant familial Meniere's disease.28
283204752017Decreased expression of semaphorin 3D is associated with genesis and development in colorectal cancer.8
290749882017Promoter-level transcriptome in primary lesions of endometrial cancer identified biomarkers associated with lymph node metastasis.7
258393272015Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability.61
260737562015CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies.24
262869622015Class 3 semaphorins expression and association with innervation and angiogenesis within the degenerate human intervertebral disc.20
258393272015Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability.61
260737562015CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies.24

Citation

Dessen P

SEMA3D (semaphorin 3D)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50589/sema3d-(semaphorin-3d)