ARHGDIA (Rho GDP dissociation inhibitor alpha)

2008-12-01  

Identity

HGNC
LOCATION
17q25.3
LOCUSID
ALIAS
GDIA1,HEL-S-47e,NPHS8,RHOGDI,RHOGDI-1
FUSION GENES

Other Information

Locus ID:

NCBI: 396
MIM: 601925
HGNC: 678
Ensembl: ENSG00000141522

Variants:

dbSNP: 396
ClinVar: 396
TCGA: ENSG00000141522
COSMIC: ARHGDIA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141522ENST00000269321P52565
ENSG00000141522ENST00000269321V9HWE8
ENSG00000141522ENST00000400721P52565
ENSG00000141522ENST00000541078P52565
ENSG00000141522ENST00000541078V9HWE8
ENSG00000141522ENST00000578351J3KS60
ENSG00000141522ENST00000579121J3KTF8
ENSG00000141522ENST00000580033J3KS60
ENSG00000141522ENST00000580685P52565
ENSG00000141522ENST00000580685V9HWE8
ENSG00000141522ENST00000581876J3KRE2
ENSG00000141522ENST00000583868J3KRY1
ENSG00000141522ENST00000584461J3QQX2

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
Vasopressin-regulated water reabsorptionKEGGko04962
Vasopressin-regulated water reabsorptionKEGGhsa04962
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
p75NTR regulates axonogenesisREACTOMER-HSA-193697
Axonal growth stimulationREACTOMER-HSA-209563
Axonal growth inhibition (RHOA activation)REACTOMER-HSA-193634
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
350660912022miR-497 promotes the migration and invasion of human medulloblast Daoy cell line through targeted regulation of ARHGDIA in vitro.0
358415282022RhoGDI1 interacts with PHLDA2, suppresses the proliferation, migration, and invasion of trophoblast cells, and participates in the pathogenesis of preeclampsia.2
350660912022miR-497 promotes the migration and invasion of human medulloblast Daoy cell line through targeted regulation of ARHGDIA in vitro.0
358415282022RhoGDI1 interacts with PHLDA2, suppresses the proliferation, migration, and invasion of trophoblast cells, and participates in the pathogenesis of preeclampsia.2
340806512021Downregulation of miR‑483‑5p inhibits TGF‑β1‑induced EMT by targeting RhoGDI1 in pulmonary fibrosis.4
340806512021Downregulation of miR‑483‑5p inhibits TGF‑β1‑induced EMT by targeting RhoGDI1 in pulmonary fibrosis.4
290591572018EphrinB1 promotes cancer cell migration and invasion through the interaction with RhoGDI1.20
293076152018Protein phosphatase 1B dephosphorylates Rho guanine nucleotide dissociation inhibitor 1 and suppresses cancer cell migration and invasion.0
290591572018EphrinB1 promotes cancer cell migration and invasion through the interaction with RhoGDI1.20
293076152018Protein phosphatase 1B dephosphorylates Rho guanine nucleotide dissociation inhibitor 1 and suppresses cancer cell migration and invasion.0
281484982017Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor Ly-GDI in platelet function: a spatial systems approach.11
284175302017Rho GDP-dissociation inhibitor α is a potential prognostic biomarker and controls telomere regulation in colorectal cancer.9
286973122017Proteome analysis of irradiated endothelial cells reveals persistent alteration in protein degradation and the RhoGDI and NO signalling pathways.5
287750022017Kindlin-2 Association with Rho GDP-Dissociation Inhibitor α Suppresses Rac1 Activation and Podocyte Injury.23
281484982017Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor Ly-GDI in platelet function: a spatial systems approach.11

Citation

Dessen P

ARHGDIA (Rho GDP dissociation inhibitor alpha)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50596/arhgdia-(rho-gdp-dissociation-inhibitor-alpha)