ARHGDIA (Rho GDP dissociation inhibitor alpha)

2008-12-01  

Identity

HGNC
LOCATION
17q25.3
LOCUSID
ALIAS
GDIA1,HEL-S-47e,NPHS8,RHOGDI,RHOGDI-1
FUSION GENES

Other Information

Locus ID:

NCBI: 396
MIM: 601925
HGNC: 678
Ensembl: ENSG00000141522

Variants:

dbSNP: 396
ClinVar: 396
TCGA: ENSG00000141522
COSMIC: ARHGDIA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141522ENST00000269321P52565
ENSG00000141522ENST00000269321V9HWE8
ENSG00000141522ENST00000400721P52565
ENSG00000141522ENST00000541078P52565
ENSG00000141522ENST00000541078V9HWE8
ENSG00000141522ENST00000578351J3KS60
ENSG00000141522ENST00000579121J3KTF8
ENSG00000141522ENST00000580033J3KS60
ENSG00000141522ENST00000580685P52565
ENSG00000141522ENST00000580685V9HWE8
ENSG00000141522ENST00000581876J3KRE2
ENSG00000141522ENST00000583868J3KRY1
ENSG00000141522ENST00000584461J3QQX2

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
Vasopressin-regulated water reabsorptionKEGGko04962
Vasopressin-regulated water reabsorptionKEGGhsa04962
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
p75NTR regulates axonogenesisREACTOMER-HSA-193697
Axonal growth stimulationREACTOMER-HSA-209563
Axonal growth inhibition (RHOA activation)REACTOMER-HSA-193634
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
204009582010Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1.151
203056512010Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA.127
238675022013ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling.81
169433222006Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling.68
247104102014miR-483-5p promotes invasion and metastasis of lung adenocarcinoma by targeting RhoGDI1 and ALCAM.60
214026972011X-linked inhibitor of apoptosis protein (XIAP) mediates cancer cell motility via Rho GDP dissociation inhibitor (RhoGDI)-dependent regulation of the cytoskeleton.42
173309462007Differential protein expression profile in the intestinal epithelium from patients with inflammatory bowel disease.41
259811712015Altered expression of CDC42 signaling pathway components in cortical layer 3 pyramidal cells in schizophrenia.37
233584182013Identification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI binding.36
223930462012RhoGDI SUMOylation at Lys-138 increases its binding activity to Rho GTPase and its inhibiting cancer cell motility.33

Citation

Dessen P

ARHGDIA (Rho GDP dissociation inhibitor alpha)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50596/arhgdia-(rho-gdp-dissociation-inhibitor-alpha)