TEAD1 (TEA domain transcription factor 1)

2009-01-01  

Identity

HGNC
TEAD1
LOCATION
11p15.3
LOCUSID
7003
ALIAS
AA,NTEF-1,REF1,TCF-13,TCF13,TEAD-1,TEF-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7003
MIM: 189967
HGNC: 11714
Ensembl: ENSG00000187079

Variants:

dbSNP: 7003
ClinVar: 7003
TCGA: ENSG00000187079
COSMIC: TEAD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187079ENST00000334310P28347
ENSG00000187079ENST00000526600E9PKB7
ENSG00000187079ENST00000527376H0YCZ6
ENSG00000187079ENST00000527575H0YEJ9
ENSG00000187079ENST00000527636H0YE88

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Hippo signalingKEGGhsa_M00683
Hippo signalingKEGGM00683
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
YAP1- and WWTR1 (TAZ)-stimulated gene expressionREACTOMER-HSA-2032785
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Hippo signaling pathway -multiple speciesKEGGko04392
Hippo signaling pathway -multiple speciesKEGGhsa04392

References

Pubmed IDYearTitleCitations
190152752008YAP regulates neural progenitor cell number via the TEA domain transcription factor.167
18516691991Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1.141
262958462015YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers.92
258651192015Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state.80
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
261734332015YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors.62
259151262015TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.57
123765442002Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation.48
150167622004A novel TEAD1 mutation is the causative allele in Sveinsson's chorioretinal atrophy (helicoid peripapillary chorioretinal degeneration).48
150167622004A novel TEAD1 mutation is the causative allele in Sveinsson's chorioretinal atrophy (helicoid peripapillary chorioretinal degeneration).48

Citation

Dessen P

TEAD1 (TEA domain transcription factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-01-01

Online version: http://atlasgeneticsoncology.org/gene/50607/tead1-(tea-domain-transcription-factor-1)