PTH (parathyroid hormone)

2009-01-01  

Identity

HGNC
PTH
LOCATION
11p15.3
LOCUSID
5741
ALIAS
FIH1,PTH1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5741
MIM: 168450
HGNC: 9606
Ensembl: ENSG00000152266

Variants:

dbSNP: 5741
ClinVar: 5741
TCGA: ENSG00000152266
COSMIC: PTH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152266ENST00000282091P01270
ENSG00000152266ENST00000529816P01270

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
213899782011Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease.332
160816462005Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis.176
199655402010Early control of PTH and FGF23 in normophosphatemic CKD patients: a new target in CKD-MBD therapy?121
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
173512762007Vitamin D, parathyroid hormone levels, and the prevalence of metabolic syndrome in community-dwelling older adults.76
219398252011Vitamin D, parathyroid hormone, and cardiovascular events among older adults.74
159622902005Effects of parathyroid hormone on Wnt signaling pathway in bone.71
201569212010Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal women.71
123643262002Parathyroid hormone stimulates receptor activator of NFkappa B ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-binding protein.69
185395562008Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice.65

Citation

Dessen P

PTH (parathyroid hormone)

Atlas Genet Cytogenet Oncol Haematol. 2009-01-01

Online version: http://atlasgeneticsoncology.org/gene/50622/pth-(parathyroid-hormone)