BST2 (bone marrow stromal cell antigen 2)

2009-01-01  

Identity

HGNC
BST2
LOCATION
19p13.11
LOCUSID
684
ALIAS
CD317,HM1.24,TETHERIN
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 684
MIM: 600534
HGNC: 1119
Ensembl: ENSG00000130303

Variants:

dbSNP: 684
ClinVar: 684
TCGA: ENSG00000130303
COSMIC: BST2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130303ENST00000252593Q10589
ENSG00000130303ENST00000252593A0A024R7H5

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381975342024BST2 promotes gastric cancer metastasis under the regulation of HOXD9 and PABPC1.0
383601992024Neuronal BST2: A Pruritic Mediator alongside Protease-Activated Receptor 2 in the IL-27-Driven Itch Pathway.0
387470162024Autophagy-related protein 5 (ATG5) interacts with bone marrow stromal cell antigen 2 (BST2) to stimulate HBV replication through antagonizing the antiviral activity of BST2.0
381975342024BST2 promotes gastric cancer metastasis under the regulation of HOXD9 and PABPC1.0
383601992024Neuronal BST2: A Pruritic Mediator alongside Protease-Activated Receptor 2 in the IL-27-Driven Itch Pathway.0
387470162024Autophagy-related protein 5 (ATG5) interacts with bone marrow stromal cell antigen 2 (BST2) to stimulate HBV replication through antagonizing the antiviral activity of BST2.0
365940822023BST2 induced macrophage M2 polarization to promote the progression of colorectal cancer.0
366023682023Interleukin-27 Promotes Divergent Effects on HIV-1 Infection in Peripheral Blood Mononuclear Cells through BST-2/Tetherin.1
369294252023BST2 regulated by the transcription factor STAT1 can promote metastasis, invasion and proliferation of oral squamous cell carcinoma via the AKT/ERK1/2 signaling pathway.3
371558542023ATG5 selectively engages virus-tethered BST2/tetherin in an LC3C-associated pathway.2
372103872023CD317 maintains proteostasis and cell survival in response to proteasome inhibitors by targeting calnexin for RACK1-mediated autophagic degradation.1
372113212023Understanding how transmembrane domains regulate interactions between human BST-2 and the SARS-CoV-2 accessory protein ORF7a.2
378188012023Tetherin antagonism by SARS-CoV-2 ORF3a and spike protein enhances virus release.8
379222532023Human BST2 inhibits rabies virus release independently of cysteine-linked dimerization and asparagine-linked glycosylation.1
381406052023Tetherin Restricts SARS-CoV-2 despite the Presence of Multiple Viral Antagonists.2

Citation

Dessen P

BST2 (bone marrow stromal cell antigen 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-01-01

Online version: http://atlasgeneticsoncology.org/gene/50634/bst2-(bone-marrow-stromal-cell-antigen-2)