IL19 (interleukin 19)

2009-01-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
IL-10C,MDA1,NG.1,ZMDA1

Other Information

Locus ID:

NCBI: 29949
MIM: 605687
HGNC: 5990
Ensembl: ENSG00000142224

Variants:

dbSNP: 29949
ClinVar: 29949
TCGA: ENSG00000142224
COSMIC: IL19

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142224ENST00000270218Q9UHD0
ENSG00000142224ENST00000340758Q9UHD0
ENSG00000142224ENST00000620365Q9UHD0
ENSG00000142224ENST00000656872Q9UHD0
ENSG00000142224ENST00000659997Q9UHD0

Expression (GTEx)

0
1
2
3

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-19, 20, 22, 24REACTOMER-HSA-8854691

References

Pubmed IDYearTitleCitations
194304802009Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.655
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
123516242002Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
170833662006Interleukin (IL)-19, IL-20 and IL-24 are produced by and act on keratinocytes and are distinct from classical ILs.61
155571632004IL-19 induced Th2 cytokines and was up-regulated in asthma patients.47
220211942012Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway.47
123703602002IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha.45
151206472004Human interleukin-19 and its receptor: a potential role in the induction of Th2 responses.39
146751742003Epidermal overexpression of interleukin-19 and -20 mRNA in psoriatic skin disappears after short-term treatment with cyclosporine a or calcipotriol.33

Citation

Dessen P

IL19 (interleukin 19)

Atlas Genet Cytogenet Oncol Haematol. 2009-01-01

Online version: http://atlasgeneticsoncology.org/gene/50642/il19-(interleukin-19)