BHLHE41 (basic helix-loop-helix family member e41)

2009-01-01  

Identity

HGNC
LOCATION
12p12.1
LOCUSID
ALIAS
BHLHB3,DEC2,FNSS1,SHARP1,hDEC2
FUSION GENES

Other Information

Locus ID:

NCBI: 79365
MIM: 606200
HGNC: 16617
Ensembl: ENSG00000123095

Variants:

dbSNP: 79365
ClinVar: 79365
TCGA: ENSG00000123095
COSMIC: BHLHE41

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123095ENST00000242728Q9C0J9
ENSG00000123095ENST00000242728A0A024RAV8

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Circadian rhythmKEGGko04710
Circadian rhythmKEGGhsa04710
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108

References

Pubmed IDYearTitleCitations
123973592002Dec1 and Dec2 are regulators of the mammalian molecular clock.184
196798122009The transcriptional repressor DEC2 regulates sleep length in mammals.106
200721162010Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.91
228014922012SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors.86
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
162878522005RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes.69
123547712002Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes.61
182285282008Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm.60
184112972008DEC1 modulates the circadian phase of clock gene expression.51
198399952009Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia.49

Citation

Dessen P

BHLHE41 (basic helix-loop-helix family member e41)

Atlas Genet Cytogenet Oncol Haematol. 2009-01-01

Online version: http://atlasgeneticsoncology.org/gene/50651/bhlhe41-(basic-helix-loop-helix-family-member-e41)