Identity
HGNC
LOCATION
11q13.5
LOCUSID
ALIAS
ADNIV,HTRA3,VRNI,nCL-3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 726
MIM: 602537
HGNC: 1482
Ensembl: ENSG00000149260
Variants:
dbSNP: 726
ClinVar: 726
TCGA: ENSG00000149260
COSMIC: CAPN5
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Extracellular matrix organization | REACTOME | R-HSA-1474244 |
| Degradation of the extracellular matrix | REACTOME | R-HSA-1474228 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37949151 | 2024 | Role of calpain-5 in cerebral ischemia and reperfusion injury. | 1 |
| 37949151 | 2024 | Role of calpain-5 in cerebral ischemia and reperfusion injury. | 1 |
| 36369866 | 2023 | Early-onset Neovascular Inflammatory Vitreoretinopathy Due to Two de Novo CAPN5 Mutations in Chinese Patients: A Case Series. | 0 |
| 36369866 | 2023 | Early-onset Neovascular Inflammatory Vitreoretinopathy Due to Two de Novo CAPN5 Mutations in Chinese Patients: A Case Series. | 0 |
| 35398613 | 2022 | Mitochondrial calpain-5 truncates caspase-4 during endoplasmic reticulum stress. | 4 |
| 35398613 | 2022 | Mitochondrial calpain-5 truncates caspase-4 during endoplasmic reticulum stress. | 4 |
| 32707200 | 2021 | Whole-Exome Sequencing of Patients With Posterior Segment Uveitis. | 0 |
| 33607190 | 2021 | Characterization of mitochondrial calpain-5. | 0 |
| 33811937 | 2021 | The C2 domain of calpain 5 contributes to enzyme activation and membrane localization. | 6 |
| 32707200 | 2021 | Whole-Exome Sequencing of Patients With Posterior Segment Uveitis. | 0 |
| 33607190 | 2021 | Characterization of mitochondrial calpain-5. | 0 |
| 33811937 | 2021 | The C2 domain of calpain 5 contributes to enzyme activation and membrane localization. | 6 |
| 31968260 | 2020 | Structural Insights into the Unique Activation Mechanisms of a Non-classical Calpain and Its Disease-Causing Variants. | 9 |
| 31968260 | 2020 | Structural Insights into the Unique Activation Mechanisms of a Non-classical Calpain and Its Disease-Causing Variants. | 9 |
| 31110225 | 2019 | Proteomic insight into the pathogenesis of CAPN5-vitreoretinopathy. | 4 |
Citation
Dessen P
CAPN5 (calpain 5)
Atlas Genet Cytogenet Oncol Haematol. 2009-01-01
Online version: http://atlasgeneticsoncology.org/gene/50655/capn5-(calpain-5)
