CUL9 (cullin 9)

2009-01-01  

Identity

HGNC
LOCATION
6p21.1
LOCUSID
ALIAS
H7AP1,PARC
FUSION GENES

Other Information

Locus ID:

NCBI: 23113
MIM: 607489
HGNC: 15982
Ensembl: ENSG00000112659

Variants:

dbSNP: 23113
ClinVar: 23113
TCGA: ENSG00000112659
COSMIC: CUL9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112659ENST00000252050Q8IWT3
ENSG00000112659ENST00000372647E9PEZ1
ENSG00000112659ENST00000502719H0Y8H9
ENSG00000112659ENST00000506830H0YA00

Expression (GTEx)

0
5
10
15
20
25
30
35

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
125267912003Parc: a cytoplasmic anchor for p53.91
166722202006Identification of far upstream element-binding protein-1 as an authentic Parkin substrate.41
172989452007The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53.29
173323282007PARC and CUL7 form atypical cullin RING ligase complexes.28
250287172014The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells.15
221170792012Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking.14
201983152010Association of genetic variants with hemorrhagic stroke in Japanese individuals.11
182303392008Activation of p53-dependent responses in tumor cells treated with a PARC-interacting peptide.4
284818792017Cytoplasmic E3 ubiquitin ligase CUL9 controls cell proliferation, senescence, apoptosis and genome integrity through p53.4
198512962010Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.3

Citation

Dessen P

CUL9 (cullin 9)

Atlas Genet Cytogenet Oncol Haematol. 2009-01-01

Online version: http://atlasgeneticsoncology.org/gene/50656/cul9-(cullin-9)