OSBPL5 (oxysterol binding protein like 5)

2009-01-01  

Identity

HGNC
LOCATION
11p15.4
LOCUSID
ALIAS
OBPH1,ORP5
FUSION GENES

Other Information

Locus ID:

NCBI: 114879
MIM: 606733
HGNC: 16392
Ensembl: ENSG00000021762

Variants:

dbSNP: 114879
ClinVar: 114879
TCGA: ENSG00000021762
COSMIC: OSBPL5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000021762ENST00000263650Q9H0X9
ENSG00000021762ENST00000348039Q9H0X9
ENSG00000021762ENST00000389989Q9H0X9
ENSG00000021762ENST00000471998E9PRA9
ENSG00000021762ENST00000478260E9PNH0
ENSG00000021762ENST00000525498Q9H0X9
ENSG00000021762ENST00000526122E9PJE6
ENSG00000021762ENST00000530372E9PIJ6
ENSG00000021762ENST00000533234E9PPQ2
ENSG00000021762ENST00000533721E9PQB4
ENSG00000021762ENST00000534157E9PLN3
ENSG00000021762ENST00000534454H0YCD7

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Acyl chain remodelling of PSREACTOMER-HSA-1482801

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
202019242010Genome-wide association study of alcohol dependence implicates a region on chromosome 11.159
262069352015INTRACELLULAR TRANSPORT. PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts.143
212205122011A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking.83
271137562016ORP5/ORP8 localize to endoplasmic reticulum-mitochondria contacts and are involved in mitochondrial function.50
289704842017ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane.35
294723862018PI(4,5)P2 controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER-PM contact sites.31
259638402015Identification and evaluation of metastasis-related proteins, oxysterol binding protein-like 5 and calumenin, in lung tumors.15
190323662008Oxysterol binding protein-related protein-5 is related to invasion and poor prognosis in pancreatic cancer.11
125048492002Characterization and imprinting status of OBPH1/Obph1 gene: implications for an extended imprinting domain in human and mouse.7
293583262018Oxysterol-binding protein-related protein 5 (ORP5) promotes cell proliferation by activation of mTORC1 signaling.7

Citation

Dessen P

OSBPL5 (oxysterol binding protein like 5)

Atlas Genet Cytogenet Oncol Haematol. 2009-01-01

Online version: http://atlasgeneticsoncology.org/gene/50662/osbpl5-(oxysterol-binding-protein-like-5)