OSBPL5 (oxysterol binding protein like 5)

2009-01-01  

Identity

HGNC
LOCATION
11p15.4
LOCUSID
ALIAS
OBPH1,ORP5
FUSION GENES

Other Information

Locus ID:

NCBI: 114879
MIM: 606733
HGNC: 16392
Ensembl: ENSG00000021762

Variants:

dbSNP: 114879
ClinVar: 114879
TCGA: ENSG00000021762
COSMIC: OSBPL5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000021762ENST00000263650Q9H0X9
ENSG00000021762ENST00000348039Q9H0X9
ENSG00000021762ENST00000389989Q9H0X9
ENSG00000021762ENST00000471998E9PRA9
ENSG00000021762ENST00000478260E9PNH0
ENSG00000021762ENST00000525498Q9H0X9
ENSG00000021762ENST00000526122E9PJE6
ENSG00000021762ENST00000530372E9PIJ6
ENSG00000021762ENST00000533234E9PPQ2
ENSG00000021762ENST00000533721E9PQB4
ENSG00000021762ENST00000534157E9PLN3
ENSG00000021762ENST00000534454H0YCD7

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Acyl chain remodelling of PSREACTOMER-HSA-1482801

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
373146292023ORP5 promotes migration and invasion of cervical cancer cells by inhibiting endoplasmic reticulum stress.1
373146292023ORP5 promotes migration and invasion of cervical cancer cells by inhibiting endoplasmic reticulum stress.1
325709812020ORP5 and ORP8: Sterol Sensors and Phospholipid Transfer Proteins at Membrane Contact Sites?10
325709812020ORP5 and ORP8: Sterol Sensors and Phospholipid Transfer Proteins at Membrane Contact Sites?10
293583262018Oxysterol-binding protein-related protein 5 (ORP5) promotes cell proliferation by activation of mTORC1 signaling.15
294723862018PI(4,5)P(2) controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER-PM contact sites.93
297481342018Oxysterol-binding protein related-proteins (ORPs) 5 and 8 regulate calcium signaling at specific cell compartments.17
293583262018Oxysterol-binding protein-related protein 5 (ORP5) promotes cell proliferation by activation of mTORC1 signaling.15
294723862018PI(4,5)P(2) controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER-PM contact sites.93
297481342018Oxysterol-binding protein related-proteins (ORPs) 5 and 8 regulate calcium signaling at specific cell compartments.17
289704842017ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P (2)) and regulate its level at the plasma membrane.85
289704842017ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P (2)) and regulate its level at the plasma membrane.85
271137562016ORP5/ORP8 localize to endoplasmic reticulum-mitochondria contacts and are involved in mitochondrial function.122
271137562016ORP5/ORP8 localize to endoplasmic reticulum-mitochondria contacts and are involved in mitochondrial function.122
259638402015Identification and evaluation of metastasis-related proteins, oxysterol binding protein-like 5 and calumenin, in lung tumors.34

Citation

Dessen P

OSBPL5 (oxysterol binding protein like 5)

Atlas Genet Cytogenet Oncol Haematol. 2009-01-01

Online version: http://atlasgeneticsoncology.org/gene/50662/osbpl5-(oxysterol-binding-protein-like-5)