CHP1 (calcineurin like EF-hand protein 1)

2009-02-01  

Identity

HGNC
LOCATION
15q15.1
LOCUSID
ALIAS
CHP,SLC9A1BP,SPAX9,Sid470p,p22,p24

Other Information

Locus ID:

NCBI: 11261
MIM: 606988
HGNC: 17433
Ensembl: ENSG00000187446

Variants:

dbSNP: 11261
ClinVar: 11261
TCGA: ENSG00000187446
COSMIC: CHP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187446ENST00000334660Q99653
ENSG00000187446ENST00000334660A0A024R9M9
ENSG00000187446ENST00000392151F5GX29
ENSG00000187446ENST00000560397H0YNG9
ENSG00000187446ENST00000560411H0YLX1
ENSG00000187446ENST00000560784H0YKE7
ENSG00000187446ENST00000560965H0YLY7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Hyaluronan metabolismREACTOMER-HSA-2142845
Hyaluronan uptake and degradationREACTOMER-HSA-2160916

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
191655272009Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.56
122261012002Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger.23
150356332004Role of calcineurin B homologous protein in pH regulation by the Na+/H+ exchanger 1: tightly bound Ca2+ ions as important structural elements.22
170505402007Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1.15
186289882008Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease.9
188151282008CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells.9
308463172019CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4.9
210851262011SNPs in axon guidance pathway genes and susceptibility for Parkinson's disease in the Korean population.7
165112062005Crystallization and preliminary crystallographic analysis of the human calcineurin homologous protein CHP2 bound to the cytoplasmic region of the Na+/H+ exchanger NHE1.4

Citation

Dessen P

CHP1 (calcineurin like EF-hand protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-02-01

Online version: http://atlasgeneticsoncology.org/gene/50667/chp1-(calcineurin-like-ef-hand-protein-1)